B12-deficiency anemia combined with active cytomegalovirus infection in a one-year-old child
https://doi.org/10.34680/2076-8052.2023.2(131).312-321
Abstract
The article presents a clinical case of B12-deficiency anemia in combination with active cytomegalovirus infection in a one-year-old child. This type of anemia is extremely rare in childhood, under certain circumstances, including the enthusiasm for restrictive diets among young patients’ mothers. In the described case, severe megaloblastic macrocytic anemia was combined with generalized cytomegalovirus infection, which aggravated the course and prognosis of the disease. These pathologies led to damage of the central nervous system with a tempo neurological deficit, as well as the development of protein-energy insufficiency. Complex therapy included hemotransfusion of erythrocyte mass, injections of anticytomegalovirus immunoglobulin and cyanocobalamin. The general condition of the child improved, recovery of previously lost skills and significant positive laboratory dynamics were noted after the therapy.
About the Authors
N. G. Larina
Yaroslav-the-Wise Novgorod State University
Russian Federation
Russian Federation
Larina N. G.,
Veliky Novgorod.
K. N. Pavlova
Yaroslav-the-Wise Novgorod State University; Regional Children's Clinical Hospital
Russian Federation
Russian Federation
Pavlova K. N.,
Veliky Novgorod.
E. V. Naumova
Yaroslav-the-Wise Novgorod State University; Regional Children's Clinical Hospital
Russian Federation
Russian Federation
Naumova E. V.,
Veliky Novgorod.
A. D. Balashova
Yaroslav-the-Wise Novgorod State University
Russian Federation
Russian Federation
Balashova A. D.,
Veliky Novgorod.
References
1. Vdovichenko V. P., Bronskaya G. M., Borisenko O. A., Korshak T. A. Faktory riska razvitiya deficita vitamina V12 i ego posledstviya [Risk factors for vitamin B12 deficiency and its consequences] // Meditsinskie Novosti. 2019. 8(299). 13-18.
2. Barkhatov M. V., Falaleeva S. O., Shishkina E. V., Denisova Yu. E., Borisova E. V., Krasitsky A. I., Makarevskaya N. Yu. Paroksizmal'nye narusheniya u detej pri zamestitel'noj terapii vitaminom B12 [Paroxysmal disorders in children with vitamin B12 replacement therapy] // Russian Journal of Child Neurology. 2017. 12(4). 43-49.DOI: 10.17650/2073-8803-2017-12-4-43-49
3. Dror D. K., Allen L. H. Effect of vitamin B12 deficiency on neurodevelopment in infants: current knowledge and possible mechanisms // Nutrition Reviews. 2008. 66(5). 250-255. DOI: 10.1111/j.1753-4887.2008.00031.x
4. Shchugareva L. M., Sokolova N. E., Omelianenko A. A., Politova Yu. G. Nevrologicheskie osobennosti b 12-deficitnoj anemii u detej [Neurological features of b12-deficient anemia in children] // The Neurological Journal. 2012. 17(1). 15-20.
5. Krasnovsky A. L., Grigoriev S. P., Alyokhina R. M., Ezhova I. S., Zolkina I. V., Loshkareva E. O. Sovremennye vozmozhnosti diagnostiki i lecheniya deficita vitamina B12 [Modern possibilities of diagnosis and treatment of vitamin B12 deficiency] // The Clinician. 2016. 10(3). 15-25. DOI: 10.17650/1818-8338-2016-10-3-15-25
6. Argunova E. F., Kondratieva S. A., Andreeva O. V., Protopopova N. N. Megaloblastnye anemii u detej [Megaloblastic anemia in children] // Vestnik of the Northeastern Federal University named after M. K. Ammosov. 2018. 3(12). 12-16. DOI: 10.25587/SVFU.2018.3(13).18850
7. Kashyape S. S., Kashyape P. S., Kakade G. M. Megaloblastic anemia in a child with central nervous system manifestation // The Indian Journal of Pediatrics Indian. 2006. 73(1). 109-110. DOI: 10.1007/BF02758280
8. Katar S., Nuri O. M., Yaramis A., Ecer S. Nutritional megaloblastic anemia in young Turkish children is associated with vitamin B12 deficiency and psychomotor retardation // Journal of Pediatric Hematology/oncology. 2006. 28(9). 559-562. DOI: 10.1097/01.mph.0000212958.89091.c0
Review
For citations:
Larina N.G., Pavlova K.N., Naumova E.V., Balashova A.D. B12-deficiency anemia combined with active cytomegalovirus infection in a one-year-old child. Title in english. 2023;(2(131)):312-321. (In Russ.) https://doi.org/10.34680/2076-8052.2023.2(131).312-321
Views:
76
Email this article 