Morphological indicators of liver tissue state in cholestasis before and after decompression
https://doi.org/10.34680/2076-8052.2021.1(122).28-32
Abstract
The morphological state of the liver was analyzed in 145 patients with cholestasis of non-neoplastic etiology, who were treated at the Novgorod Regional Clinical Hospital and the Central City Clinical Hospital of Veliky Novgorod. The results of liver biopsy during surgery, as well as puncture liver biopsy 5 days and 3 weeks after decompression operations were studied. There were pronounced structural and functional changes in liver tissue that progressed with increasing duration of occlusion. In cases with prolonged chronic jaundice, after decompression of the bile ducts, sclerotic changes, histiolymphocytic infiltration and proliferating biliary epithelium remain in the portal tracts. The study of puncture and intraoperative biopsies in obstructive jaundice makes it possible to determine the form and severity of cholestasis, which, together with other data, affects the prognosis of the disease and the tactics of surgical treatment. With cholestasis of varying duration, it is necessary to carry out measures as early as possible aimed at correcting violations of liver morphology.
About the Authors
T. K. Dubovaya
Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Moscow
I. G. Proshina
Novgorod State University
Russian Federation
Russian Federation
Veliky Novgorod
M. D. Kashaeva
Novgorod State University
Russian Federation
Russian Federation
Veliky Novgorod
A. V. Proshin
Novgorod State University
Russian Federation
Russian Federation
Veliky Novgorod
K. V. Gavrilova
Novgorod State University
Russian Federation
Russian Federation
Veliky Novgorod
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Review
For citations:
Dubovaya T.K., Proshina I.G., Kashaeva M.D., Proshin A.V., Gavrilova K.V. Morphological indicators of liver tissue state in cholestasis before and after decompression. Title in english. 2021;(1(122)):28-32. https://doi.org/10.34680/2076-8052.2021.1(122).28-32
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