Structural changes in the liver tissue with long-term obstructive jaundice of non-tumor etiology
https://doi.org/10.34680/2076-8052.2022.2(127).34-37
Abstract
Histological preparations of liver tissue were studied in 82 patients with long-term (more than two weeks) obstructive jaundice of non-tumor etiology, who were treated at the Novgorod Regional Clinical Hospital in the period from 2014 to 2021. There is a twofold increase in the stroma, due to the development of connective tissue; destruction of blood capillaries is revealed, which entails a deterioration in the blood circulation of the liver; a decrease in the volume of the nucleus and cytoplasm is detected with obstructive jaundice, which indicates an increase in necrotic processes; structural changes appear in the intrahepatic bile ducts and their filling with lipocytes, the functional activity of hepatocytes slows down, the rate of their division decreases, all types of exchanges slow down. Studies of the liver tissue in obstructive jaundice make it possible to determine the form and severity of cholestasis, which, together with other data, affect the prognosis of the disease and the determination of therapeutic tactics. Repeated puncture biopsies of the liver allow you to monitor the condition of the liver after decompression and determine the effectiveness of the treatment.
About the Authors
M. D. Kashaeva
Новгородский государственный университет имени Ярослава Мудрого
Russian Federation
Russian Federation
A. V. Proshin
Новгородский государственный университет имени Ярослава Мудрого; Городская клиническая больница им. В.В. Вересаева
Russian Federation
Russian Federation
L. G. Proshina
Новгородский государственный университет имени Ярослава Мудрого
Russian Federation
Russian Federation
D. A. Shvetsov
Новгородский государственный университет имени Ярослава Мудрого
Russian Federation
Russian Federation
T. K. Dubovaya
Российский национальный исследовательский медицинский университет имени Н.И. Пирогова
Russian Federation
Russian Federation
K. V. Gavrilova
Новгородский государственный университет имени Ярослава Мудрого
Russian Federation
Russian Federation
References
1. Aliyev M.A., Andreev G.N., Tashev I.A., Doskaliev Zh.A. Khirurgicheskaya korrektsiya khronicheskikh gepatitov i tsirrozov pecheni [Surgical correction of chronic hepatitis and cirrhosis of the liver]. Veliky Novgorod, 2001. 140 p.
2. Borisov A.E., Zemlyanoi V.P., Kashchenko V.A., Ayaganov. Znacheniye laparoskopicheskoy biopsii pecheni u bol'-nykh s zhelchnokamennoy bolezn'yu: Tezisy dokladov X Vserossiyskogo s"yezda po endoskopicheskoy khirurgii [The significance of laparoscopic liver biopsy in patients with cholelithiasis: Abstracts of the X All-Russian Congress on Endoscopic Surgery]. Endoskopicheskaya khirurgiya — Endoscopic surgery, 2012, no. 2, pp. 19–20.
3. Nagorny V.A., Sedov A.P., Parfenov I.P. Morfofunktsional'noye sostoyaniye pecheni posle ustraneniya vnepechenochnogo kholestaza [Morphofunctional state of the liver after elimination of extrahepatic cholestasis] Aktual'nyye problemy sovremennoy khirurgii. Sb. rabot. SPb — Actual Problems of Modern Surgery. Collection of Works. SPb., 2011, pp. 103–105.
4. Sotnichenko B.A., Goncharov K.V. Kholedokholitiaz u bol'nykh pozhilogo i starcheskogo vozrasta [Choledocholithiasis in elderly and senile patients]. Vestnik khirurgii — Bulletin of Surgery, 2001, vol. 160, no. 2, pp. 113–118.
5. Tsyrkunov V. M., Andreev V. P., Prokopchik N. I., Kravchuk R. I. Klinicheskaya morfologiya pecheni: distrofii [Clinical morphology of the liver: dystrophy]. Gepatologiya i gastroenterologiya — Hepatology and Gastroenterology, 2017, vol. 1 (2), pp. 140–151
6. Yamaguti D.C., Patricio F.R. Morphometrical and immunohistochemical study of intrahepatic bile ducts in biliary atresia. Eur. J. Gastroenterol. Hepatol., 2011, vol. 23(9), pp. 759–765. doi: https://doi.org/10.1097/MEG.0b013e32832e9df0
7. Permutt Z., Le T.A., Peterson M.R., et al. Correlation between liver histology and novel magnetic resonance imaging in adult patients with non-alcoholic fatty liver disease — MRI accurately quantifies hepatic steatosis in NAFLD. Alimentary Pharmacology and Therapeutics, 2012, vol. 36(1), pp. 22–29. doi: https://doi.org/10.1111/j.13652036.2012.05121.x
8. Mehtiev, S. N., Mehtieva O. A. Zhelchnokamennaya bolezn' i nealkogol'naya zhirovaya bolezn' pecheni: sochetaniye i prognoz [Cholelithiasis and non-alcoholic fatty liver disease: Combination and prognosis]. Lechashchiy vrach — Attending Physician, 2017, vol. 3, pp. 77–82.
Review
For citations:
Kashaeva M.D., Proshin A.V., Proshina L.G., Shvetsov D.A., Dubovaya T.K., Gavrilova K.V. Structural changes in the liver tissue with long-term obstructive jaundice of non-tumor etiology. Title in english. 2022;(2(127)):34-37. (In Russ.) https://doi.org/10.34680/2076-8052.2022.2(127).34-37
Views:
45
Email this article 