Macrophages in tissue microenvironment of non-small cell lung cancer
https://doi.org/10.34680/2076-8052.2022.1(126).70-74
Abstract
The article explores the role of tumor-associated macrophages in the development, course, and resistance of non-small cell lung cancer, as well as potential drug targets. The place of tumor-associated macrophages in the tumor tissue, the variants of their differentiation, the patterns of their interaction with cancer cells and other components of the tumor microenvironment are described. Local and recruited tumor-associated macrophages interact with tumor cells, stimulating their reproduction, invasion, metastasis; with tumor immunocytes, suppressing their activity, causing the tumor to escape the immune response; and are also involved in processes limiting the effectiveness of antitumor treatment. The features of the prognostic significance of the content, the polarization of macrophages in the tumor, of the receptors and cytokines expressed by them are indicated. Potential therapeutic targets connected with tumor-associated fibroblasts and their activity are listed.
About the Author
Ye. Ye. Rumyantsev
Новгородский государственный университет имени Ярослава Мудрого
Russian Federation
Russian Federation
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Review
For citations:
Rumyantsev Ye.Ye. Macrophages in tissue microenvironment of non-small cell lung cancer. Title in english. 2022;(1(126)):70-74. (In Russ.) https://doi.org/10.34680/2076-8052.2022.1(126).70-74
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