Efficiency of ozonotherapy in treatment of endotoxicosis in patients with purous destructive diseases of the lungs and pleura

The analysis of the results of treatment of 101 patients with purulent-destructive diseases of the lungs and pleura, depending on the implementation of ozone therapy is carried out. With this in mind, patients were divided into 2 groups. Group I included 50 patients with purulent-destructive diseases of the lungs and pleura, who underwent standard antibiotic therapy and surgical treatment. Surgical treatment included thoracotomy, pleurectomy and, according to indications, lobectomy. Of these, abscesses of the lung lobe were revealed in 19 (38.0%) patients, and pleura empyema in 31 (62.0%). In group II, 51 patients in combination with traditional antibiotic therapy and surgical treatment, additionally carried out local and general (intravenous infusion) ozone therapy. Of these, 16 (31.4%) were diagnosed with lung abscess, and the remaining 35 (68.6%) had pleural empyema. The criteria for analysis were the dynamics of lipid peroxidation (LP) and antioxidant activity (AOA) of blood plasma, as well as medium-weight molecules (MSM), reflecting the state of endogenous intoxication upon admission and its change during treatment. A comparative analysis of the treatment results in the studied groups showed that the use of ozone therapy in group II promotes the mobilization and activation of the body’s defenses, normalization of lipid peroxidation processes and activation of antioxidant protection, which results in an improvement in treatment outcomes, which allows substantiating the etiopathogenetic expediency of its use in this pathology.

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