Anti-radical activity of northern berries polyphenol extracts and their influence on blood oxidation status
https://doi.org/10.34680/2076-8052.2022.1(126).47-51
Abstract
The aim of the work was to evaluate the effect of polyphenolic extracts of northern berries (bilberries, cranberries, lingonberries, blueberries) on the level of free radicals in vitro and antioxidant defense processes in vivo. Standard research methods were used. Polyphenolic water-alcohol extracts were obtained from bilberries, cranberries, lingonberries, blueberries collected in the Surgut region of the Khanty-Mansiysk district of the Tyumen oblast of the Russian Federation. The inhibitory, antiradical activity of extracts of Vaccinium berries was established in DPPH and ABTS tests. Antioxidant activity was found in vivo in D-ROM and PAT tests, as well as in the test of oxidative hemolysis of rat erythrocytes after the administration of polyphenol extracts from cranberries, lingonberries, blueberries, and bilberries for 10 days. It is assumed that polyphenolic extracts of northern berries have the potential to influence the oxidative status of the body due to the presence of antiradical properties and the ability to increase the level of antioxidant protection.
About the Authors
E. A. Belova
Сургутский государственный университет
Russian Federation
Russian Federation
N. S. Kavushevskaya
Сургутский государственный университет
Russian Federation
Russian Federation
E. A. Krivykh
Ханты-Мансийская государственная медицинская академия
Russian Federation
Russian Federation
L. V. Kovalenko
Сургутский государственный университет
Russian Federation
Russian Federation
References
1. Golovinskaia O., Chin-Kun W. Review of Functional and Pharmacological Activities of Berries. Moleculesvol, 2021, vol. 26(13), p. 3904. doi:10.3390/molecules26133904
2. Scarmeas N., Anastasiou C.A., Yannakoulia M. Nutrition and prevention of cognitive impairment. Lancet Neurol, 2018, vol. 17, pp. 1006–1015.
3. Xu Xiaoyue et al. The Joint Effects of Diet and Dietary Supplements in Relation to Obesity and Cardiovascular Disease over a 10-Year Follow-Up: A Longitudinal Study of 69,990 Participants in Australia. Nutrients, 2021, vol. 13(3), p. 944. doi: 10.3390/nu13030944
4. Behl, Tapan, et al. Elucidating the Multi-Targeted Role of Nutraceuticals: A Complementary Therapy to Starve Neurodegenerative Diseases. International journal of molecular sciences, 2021, vol. 22(8), p. 4045. doi: 10.3390/ijms22084045
5. Re R., Pellegrini N., Proteggente А., et al. Antioxidаnt асtivity аpplying аn improved АBTS rаdiсаl саtion deсolorizаtion аssаy. Free Radical Biology and Medicine, 1999, vol. 26, pp. 1231–1237. doi: 10.1016/S0891-5849(98)00315-3
6. Prikaz Ministerstva zdravookhraneniya i sotsial'no-go razvitiya RF No. 708n “Ob utverzhdenii Pravil la-boratornoy praktiki” [Order of the Ministry of Health and Social Development of the Russian Federation No. 708n “On Approval of the Rules of Laboratory Practice”]. Available at: http://www.roszdravnadzor.ru/drugs/controllslp
7. Inchingolo F., Marrelli M., Annibali S. et al. Influence of endodontic treatment on systemic oxidative stress. Int. J. Med. Sci., 2014, vol. 11, pp. 1-6.
8. Ito F., Ito H., Suzuki Ch., Yahata T., Ikeda K., Hamaoka K. The Application of a Modified d-ROMs Test for Measurement of Oxidative Stress and Oxidized High-Density Lipoprotein. Int. J. Mol. Sci., 2017, vol. 18(2), p. 454.
9. Vives M.A., Infante M.R., Garcia E., Selve C., Maugras M., Vinardell M.P. Erythrocyte hemolysis and shape changes induced by new lysine-derivate surfactants. Chem. Biol. Interact., 1999, 118, pp.1-18.
10. Pullar, Vissers M., Winterbourn C. Living with a killer: the effects of hypo-chlorous acid on mammalian cells // IUBMB Life. 2001. Vol.50. P.259–266.
11. Vissers M.C., Stern A., Kuypers F., van den Berg J., Winterbourn C.C. Membranechanges associated with lysis of red blood cells by hypochlorous acid // Free Radic.Biol. 1994. Vol.16. P.703–712.
12. Hawkins C.L., Brown B.E., Davies M.J. Hypochloriteand hypobromite-mediated radical formation and its role in cell lysis. Arch. Biochem. Biophys., 2001, vol. 395(2), pp. 137145.
13. Shumaev K.B., Gorudko I.V., Kosmachevskaya O.V. et al. Protective Effect of Dinitrosyl Iron Complexes with Glutathione in Red Blood Cell Lysis Induced by Hypochlorous Acid. Oxid. Med. Cell Longev., 2019, art. no. 2798154. doi: 10.1155/2019/2798154
14. Zavodnik I.B., Lapshina E.A., Zavodnik L.B., Soszyński M., Bartosz G., Bryszewska M Hypochlorous acid-induced oxidative damage of human red blood cells: effects of tert-butyl hydroperoxide and nitrite on the HOCl reaction with erythrocytes. Bioelectrochemistry, 2002, vol. 58(2), pp. 127135.
15. Colina J.R., Suwalsky M., Manrique-Moreno M., Petit K., Aguilar L.F., Jemiola-Rzeminska M., Strzalka K. Protective effect of epigallocatechin gallate on human erythrocytes. Colloids Surf B Biointerfaces, 2019, vol. 173, pp. 742-750.
16. Ungarala, Ramakrishna et al. Assessment of Antioxidant, Immunomodulatory Activity of Oxidised Epigallocatechin-3Gallate (Green Tea Polyphenol) and Its Action on the Main Protease of SARS-CoV-2-An In Vitro and In Silico Approach. Antioxidants, 2022, vol. 11(2), p. 294. doi:10.3390/antiox11020294
17. Akter, Rokeya et al. Chemo-Preventive Action of Resveratrol: Suppression of p53-A Molecular Targeting Approach. Molecules, 2021, vol. 26(17), p. 5325. doi: 10.3390/molecules26175325
18. Rudrapal, Mithun et al. Dietary Polyphenols and Their Role in Oxidative Stress-Induced Human Diseases: Insights Into Protective Effects, Antioxidant Potentials and Mechanism(s) of Action. Frontiers in pharmacology, 2022, vol. 13, 806470. doi: 10.3389/fphar.2022.806470
Review
For citations:
Belova E.A., Kavushevskaya N.S., Krivykh E.A., Kovalenko L.V. Anti-radical activity of northern berries polyphenol extracts and their influence on blood oxidation status. Title in english. 2022;(1(126)):47-51. (In Russ.) https://doi.org/10.34680/2076-8052.2022.1(126).47-51
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