Age-related changes in blood renin levels in healthy individuals and patients with arterial hypertension
https://doi.org/10.34680/2076-8052.2025.2(140).332-340
Abstract
The article presents the results of a study on the age-related dynamics of plasma renin levels in healthy individuals and patients with arterial hypertension, including both men and women in different age groups: young adults (25–44 years), middle-aged adults (45–59 years), and older adults (60 years and older). The study revealed the following pattern: with age, healthy men and women showed a progressive and significant decrease in plasma renin levels compared to the young adult group. In contrast, patients with arterial hypertension demonstrated a significant increase in renin levels with age. The age-related trend in plasma renin levels was similar in men and women but was more pronounced in men.
About the Authors
V. R. VeberRussian Federation
Veliky Novgorod
V. A. Pavlova
Russian Federation
Veliky Novgorod; Pskov
A. A. Pavlova
Russian Federation
Veliky Novgorod
M. M. Mamontova
Russian Federation
Veliky Novgorod
References
1. Santos R. A. S., Oudit G. Y., Verano-Braga T., Canta G., Steckelings U. M., Bader M. The renin-angiotensin system: going beyond the classical paradigms // American journal of physiology. Heart and circulatory physiology. 2019. 316 (5). H958–H970. DOI: 10.1152/ajpheart.00723.2018
2. Karlovich N. V., Mokhort T. V., Volchek Yu. A. Renin-angiotensin-aldosterone system: traditional function and pleiotropic effects of regulation of phosphorus-calcium metabolism // Medical news. 2021. 10 (325). 22–26. (In Russian).
3. Dzhanashia P. H., Selivanova G. B. Age-related differences in the dynamics of blood pressure, the state of the renin-aldosterone system and the blood lipid spectrum in hypertension due to thyrotoxicosis // Russian Journal of Cardiology. 2003. 6 (44). 16–23. (In Russian).
4. Alnazer R. M., Veldhuizen G. P., de Leeuw P. W., Kroon A. A. The effect of age, sex and BMI on the aldosterone-to-renin ratio in essential hypertensive individuals // Journal of hypertension. 2023. 41 (4). 618–623. DOI: 10.1097/HJH.0000000000003377
5. Pavlova V. A., Pavlova A. A., Weber V. R., Zhmailova S. V. Diagnostic significance of laboratory study of renin levels in blood in patients with hypertension // Vestnik NovSU. 2024. 2 (136). 265–274. DOI: 10.34680/2076-8052.2024.2(136).265-274 (In Russian).
6. Lifton R. P., Gharavi A. G., Geller D. S. Molecular mechanisms of human hypertension // Cell. 2001. 104 (4). 545–556. DOI: 10.1016/s0092-8674(01)00241-0
7. Oelkers W. K. Effects of estrogens and progestogens on the renin-aldosterone system and blood pressure // Steroids. 1996. 61 (4). 166–171. DOI: 10.1016/0039-128x(96)00007-4
8. Hall J. E., Guyton A. K. Medical physiology according to Guytonand Hall: textbook / transl. from English. 2 ed., ispr. and add. Moscow: Logosphere Publ., 2018. 1174 p. (In Russian).
9. Schuckert H., Danser A. H., Hesse H. W., Dark F. H., Kürzinger S., Rieger G. A. Effects of estrogen replacement therapy on the renin-angiotensin system in postmenopausal women // Circulation. 1997. 95 (1). 39–45. DOI: 10.1161/01.CIR.95.1.39
10. Filatova V. A., Rozhivanov R. V., Bondarenko I. Z., Ioutsi V. A., Andreeva E. N., Melnichenko G. A., Mokrysheva N. G. Features of steroidogenesis and arterial hypertension in men with different types of "physiological" hyperandrogenism in men // Problems of Endocrinology. 2023. 69 (2). 80–91. DOI: 10.14341/probl13226 (In Russian).
11. Khripun I. A., Vorobyov S. V. The effect of testosterone on endothelial function in men with type 2 diabetes mellitus // South Russian journal of therapeutic practice. 2021. 2 (3). 78–85. DOI: 10.21886/2712-8156-2021-2-3-78-85 (In Russian).
12. Kienitz T., Quinkler M. Testosterone and blood pressure regulation // Kidney and blood pressure research. 2008. 31 (2). 71–79. DOI: 10.1159/000119417
13. Dadashova G. M. Gender differences renin-angiotensin-aldosterone system and its relation to humoral factors in patients with arterial hypertension // Systemic Hypertension. 2015. 12 (3). 34–38. (In Russian).
14. Novak V. D., Haisheva L. A. Aspects of arterial hypertension in young adults with obesity // South Russian Journal of Therapeutic Practice. 2024. 5 (3).14–20. DOI: 10.21886/2712-8156-2024-5-3-14-20 (In Russian).
15. Weidmann P., De Myttenaere-Bursztein S., Maxwell M.H., de Lima J. Effect of aging on plasma renin and aldosterone in normal man // Kidney international. 1975. 8 (5). 325–333. DOI: 10.1038/ki.1975.120
16. Guyton A. C., Hall J. E. Textbook of Medical Physiology. 12th ed. Philadelphia: Saunders, 2010. 1091 р.
17. Rule A. D., Amer H., Cornell L. D., Taler S. J., Cosio F. G., Kremers W. K., Textor S. C., Stegall M. D. The association between age and nephrosclerosis on renal biopsy among healthy adults // Annals of internal medicine. 2010. 152 (9). 561–567. DOI: 10.7326/0003-4819-152-9-201005040-00006
18. Mulatero P., Monticone S., Deinum J., Amer L., Prejbisz A., Zennaro M.-C., Beuschlein F., Rossi G. P., Nishikawa T., Morganti A., Seccia T. M., Lin Y.-H., Fallo F., Widimsky J. Genetics, prevalence, screening and confirmation of primary aldosteronism: a position statement and consensus of the Working Group on Endocrine Hypertension of The European Society of Hypertension // Hypertension. 2020. 38 (10). 1919–1928. DOI: 10.1097/HJH.0000000000002510
19. Barsukov A. V., Korneychuk N. N., Shustov S. B. High-renin hypertensions: from symptom to diagnosis // Herald of the Northwestern State Medical University named after I.I. Mechnikov.2017. 9 (2). 7–18. (In Russian).
20. Reckelhoff J. F., Fortepiani L. A. Novel mechanisms responsible for postmenopausal hypertension // Hypertension. 2004. 43 (5). 918–923. DOI: 10.1161/01.HYP.0000124670.03674.15
Review
For citations:
Veber V.R., Pavlova V.A., Pavlova A.A., Mamontova M.M. Age-related changes in blood renin levels in healthy individuals and patients with arterial hypertension. Title in english. 2025;(2(140)):332-340. (In Russ.) https://doi.org/10.34680/2076-8052.2025.2(140).332-340