Роль микроРНК в регуляции окислительного стресса при эндометриозе

Микрорибонуклеиновые кислоты (микроРНК) – короткие одноцепочечные некодирующие рибонуклеиновые кислоты. МикроРНК участвуют в регуляции многих процессов, участвующих в поддержании гомеостаза в норме, а также в патогенезе многих заболеваний, в частности, их роль подтверждена в формировании окислительного стресса. В основе окислительного стресса лежит гиперпродукция активных форм кислорода и/или дефицит антиоксидантов. В настоящее время окислительный стресс рассматривается как одно из ключевых звеньев патогенеза эндометриоза. Была доказана роль ряда микроРНК (miR-21, miR-23a, miR-30a, miR-34a, miR-125b, miR-132, miR-146a, miR-155, miR-200c, miR-205, miR-484, miR-6516-5p) в регуляции окислительного стресса за счет прямого и опосредованного действия на транскрипцию антиоксидантных ферментов. В связи с участием в регуляции редокс-статуса при эндометриозе микроРНК могут выступать в роли потенциальных диагностических и прогностических маркеров эндометриоза, включая оценку тяжести и прогрессирование по стадиям.

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