Delayed morphological changes in the lungs during experimental aspiration injury

Abstract

Aspiration pneumonia has a fairly large proportion among severe pneumonias and a high mortality rate. This article discusses some morphological aspects of changes in the lungs of experimental animals after aspiration of acidin-pepsin into the respiratory tract. As an object of study, white mongrel rats were used, formed according to the principle of pairs of analogues, with the allocation of experimental and control groups. On the 21st day of the experiment, the animals were removed from the experiment. As a result, morphological examination revealed a pronounced reaction of the pulmonary parenchyma. In all experimental animals, damage to the mucous membrane of the bronchi and bronchioles, circulatory disorders, cellular inflammatory infiltration, the development of atelectasis, dystelectasis, and emphysema were noted.