Topical nasal decongestants: range and application aspects
https://doi.org/10.34680/2076-8052.2024.4(138).595-608
Abstract
The problem of the prevalence of upper respiratory tract diseases, including acute and chronic rhinosinusitis, requires timely, high-quality medical and pharmaceutical care. Decongestants are the basis of rhinosinusitis therapy. The results of studying the range of adrenomimetics (code R01AA) are presented. The set of vasoconstrictive nasal medication is characterized by a wide range, 15 international nonproprietary names (INN) and their combinations are represented on the pharmaceutical market. To facilitate breathing, patients often independently use over-the-counter vasoconstrictors in the form of various dosage forms, while timely assistance from a pharmaceutical worker is important. When choosing a drug for the treatment of acute and chronic rhinitis, one of the fundamental factors is the duration of the therapeutic effect and the absence of side effects. Oxymetazoline's leading position among modern decongestants is explained by its use only twice a day. The article shows the processes of a significant increase in the release of oxymetazoline in various dosage forms. The pharmaceutical market has a sufficient range of decongestants in the form of modern dosage forms.
About the Authors
G. A. Antropova
Yaroslav-the-Wise Novgorod State University
Russian Federation
Russian Federation
Veliky Novgorod
E. S. Egorova
Yaroslav-the-Wise Novgorod State University
Russian Federation
Russian Federation
Veliky Novgorod
References
1. Antonov N. S., Saxarova G. M., Rusakova L. I., Salagay O. O. Dinamika zabolevayemosti boleznyami organov dykhaniya sredi naseleniya Rossiyskoy Federatsii v 2010-2022 gg. [Dynamics of the Incidence of Respiratory Diseases Among the Population of the Russian Federation in 2010-2022] // Medicina. 2023. 11 (3). 1-17. DOI: 10.29234/2308-9113-2023-11-3-1-17
2. Zabolevayemost' naseleniya Rossiyskoy Federatsii po osnovnym klassam bolezney. Federal'naya sluzhba gosudarstvennoj statistiki, Oficial'naya statistika, Zdravoohranenie. [Morbidity of the population of the Russian Federation by main classes of diseases // Federal State Statistics Service, Official statistics, Healthcare]. URL: https://rosstat.gov.ru/folder/13721 (Accessed: 02.09.2024).
3. Yevropeyskiy soglasitel'nyy dokument po rinosinusitu i nazal'nym polipam [European consensus document on rhinosinusitis and nasal polyps.]. EPOS 2020. URL: https://ms-mag.ru/epos/?ysclid=m2kxweid9f654267073 (Accessed: 02.09.2024).
4. Shilenkova V. V., Shilenkov K. A. EPOS-2020. Chto novogo? [EPOS-2020. What’s new?] // Rossiyskaya Rinologiya (Russian Rhinology). 2020. 28 (2). 94-100. DOI: 10.17116/rosrino20202802194
5. Otorinolaringologiya: natsional'noye rukovodstvo [Otolaryngology: national guidelines] / edited by V.P. Palchun. Moscow: GEOTAR-Media, 2022. 1024 р.
6. Varvyanskaya A. V., Lopatin A. S. Topicheskiye nazal'nyye dekongestanty: sravnitel'naya kharakteristika i obzor pobochnykh effektov [Topical decongestants in otorhinolaryngologist practice] // Rossiyskaya Rinologiya (Russian Rhinology). 2015. 23 (4). 50-56. DOI: 10.17116/rosrino201523450-56
7. Fokkens W. J., Lund V. J., Hopkins C., Hellings P. W., Kern R., Reitsma S., Toppila-Salmi S., Bernal-Sprekelsen M., Mullol J., Alobid I., Terezinha Anselmo-Lima W., Bachert C., Baroody F., von Buchwald C., Cervin A., Cohen N., Constantinidis J., De Gabory L., Desrosiers M., Diamant Z., Douglas R. G., Gevaert P. H., Hafner A., Harvey R. J., Joos G. F., Kalogjera L., Knill A., Kocks J. H., Landis B. N., Limpens J., Lebeer S., Lourenco O., Meco C., Matricardi P. M., O'Mahony L., Philpott C. M., Ryan D., Schlosser R., Senior B., Smith T. L., Teeling T., Tomazic P. V., Wang D. Y., Wang D., Zhang L., Agius A. M., Ahlstrom-Emanuelsson C., Alabri R., Albu S., Alhabash S., Aleksic A., Aloulah M., Al-Qudah M., Alsaleh S., Baban M. A., Baudoin T., Balvers T., Battaglia P., Bedoya J. D., Beule A., Bofares K. M., Braverman I., Brozek-Madry E., Richard B., Callejas C., Carrie S., Caulley L., Chussi D., de Corso E., Coste A., Hadi U. El., Elfarouk A., Eloy P. H., Farrokhi S., Felisati G., Ferrari M. D., Fishchuk R., Grayson W., Goncalves P. M., Grdinic B., Grgic V., Hamizan A. W., Heinichen J. V., Husain S., Ping T. I., Ivaska J., Jakimovska F., Jovancevic L., Kakande E., Kamel R., Karpischenko S., Kariyawasam H. H., Kawauchi H., Kjeldsen A., Klimek L., Krzeski A., Kopacheva-Barsova G., Kim S. W., Lal D., Letort J. J., Lopatin A., Mahdjoubi A., Mesbahi A., Netkovski J., Nyenbue Tshipukane D., Obando-Valverde A., Okano M., Onerci M., Ong Y. K., Orlandi R., Otori N., Ouennoughy K., Ozkan M., Peric A., Plzak J., Prokopakis E., Prepageran N., Psaltis A., Pugin B., Raftopulos M., Rombaux P., Riechelmann H., Sahtout S., Sarafoleanu C.-C., Searyoh K., Rhee C.-S., Shi J., Shkoukani M., Shukuryan A. K., Sicak M., Smyth D., Sindvongs K., Soklic Kosak T., Stjarne P., Sutikno B., Steinsvag S., Tantilipikorn P., Thanaviratananich S., Tran T., Urbancic J., Valiulius A., Vasquez de Aparicio C., Vicheva D., Virkkula P. M., Vicente G., Voegels R., Wagenmann M. M., Wardani R. S., Welge-Lussen A., Witterick I., Wright E., Zabolotniy D., Zsolt B., Zwetsloot C. P. European Position Paper on Rhinosinusitis and Nasal Polyps 2020 // Rhinology. 2020. 58 (S29). 461-464. DOI: 10.4193/Rhin20.600
8. Krivopalov A. A., Moroz N. V., Artyushkin S. A., Shamkina P. A., Zakharova G. P. Otsenka rasprostranennosti khronicheskogo rinosinusita [Assessment of prevalence of chronic rhinosinusitis] // Russian Otorhinolaryngology. 2022. 21 (5). 91-98. DOI: 10.18692/1810-4800-2022-5-91-98
9. Sedaghat A. R., Kuan E. C., Scadding G. K. Epidemiology of Chronic Rhinosinusitis: Prevalence and Risk Factors // The journal of allergy and clinical immunology. In practice. 2022. 10 (6).1395-1403. DOI: 10.1016/j.jaip.2022.01.016
10. Shamkina P. A., Krivopalov A. A., Ryazantsev S. W., Schneider N. A., Gaydukov S. S., Shardanov Z. N. Epidemiologiya khronicheskikh rinosinusitov [Epidemiology of chronic rhinosinusitis] // Modern problems of science and education. 2019. 3. DOI: 10.17513/spno.28891
11. Orlandi R. R., Kingdom T. T., Hwang P. H., Smith T. L., Alt J. A., Baroody F. M., Batra P. S., Bernal-Sprekelsen M., Bhattacharyya N., Chandra R. K., Chiu A., Citardi M. J., Cohen N. A., DelGaudio J., Desrosiers M., Dhong H.-J., Douglas R., Ferguson B., Fokkens W. J., Georgalas C., Goldberg A., Gosepath J., Hamilos D. L., Han J. K., Harvey R., Hellings P., Hopkins C., Jankowski R., Javer A. R., Kern R., Kountakis S., Kowalski M. L., Lane A., Lanza D. C., Lebowitz R., Lee H.-M., Lin S. Y., Lund V., Luong A., Mann W., Marple B. F., McMains K. C., Metson R., Naclerio R., Nayak J. V., Otori N., Palmer J. N., Parikh S. R., Passali D., Peters A., Piccirillo J., Poetker D. M., Psaltis A. J., Ramadan H. H., Ramakrishnan V. R., Riechelmann H., Roh H.-J., Rudmik L., Sacks R., Schlosser R. J., Senior B. A., Sindwani R., Stankiewicz J. A., Stewart M., Tan B. K., Toskala E., Voegels R., Wang D. Y., Weitzel E. K., Wise S., Woodworth B. A., Wormald P.-J., Wright E. D., Zhou B., Kennedy D. W. International Consensus Statement on Allergy and Rhinology: Rhinosinusitis // International Forum of Allergy and Rhinolgy. 2016. 6 (S1). S22-S209. DOI: 10.1002/alr.21695
12. Lazareva L. A., Elizbaryan I. S., Kosenko V. G. Patogeneticheskiye i kliniko-funktsional'nyye paralleli formirovaniya kognitivnykh rasstroystv pri khronicheskikh rinosinusitakh [Pathogenetic and clinical-functional parallels of formation of cognitive disorders in chronic rhinosinusitis] // Russian Otorhinolaryngology. 2023. 22(4). 81-89. DOI: 10.18692/1810-4800-2023-4-81-89
13. Bezopasnost' lekarstvennykh preparatov. Gosudarstvennyy reyestr lekarstvennykh sredstv [Safety of medicinal products. State register of medicinal products]: official website. URL: http://grls.rosminzdrav.ru/grls.aspx (Accessed: 02.09.2024).
14. Marks D., Birkkhoff M., Vil'yams G. Intranazal'noye vvedeniye lekarstv – interesnoye proshloye i zamechatel'noye budushcheye [Intranasal drug delivery – an interesting past and a bright future] // Pharmaceutical technologies and packaging. 2015. 5. 70-77.
15. Iorio A., Spencer F. A., Falavigna M., Alba C., Lang E., Burnand B., McGinn T., Hayden J., Williams K., Shea B., Wolff R., Kujpers T., Perel P., Vandvik P. O., Glasziou P., Schunemann H., Guyatt G. Use of GRADE for assessment of evidence about prognosis: rating confidence in estimates of event rates in broad categories of patients // British Medical Journal (BMJ). 2015. 350 (16-7). h870. DOI: 10.1136/bmj.h870
16. Tulupov D. A., Fedotov F. A., Karpova E. P., Grabovskaya V. A. Sovremennyye aspekty primeneniya nazal'nykh sosudosuzhivayushchikh i vspomogatel'nykh preparatov v pediatricheskoy praktike [Current aspects of use of nasal vasoconstrictors and adjunctive agents in pediatric practice] // Medical Council. 2018. 2. 114-117. DOI: 10.21518/2079-701X-2018-2-114-117
17. Krivopalov A. A., Ryazantsev S. V., Mironova E. Yu., Korkmazov A. M., Kornova N. V. Kratkaya istoriya adrenomimetikov i uluchshennyye kombinatsii v lechenii zabolevaniy verkhnikh dykhatel'nykh putey [A brief history of adrenergic drugs and improved combinations in the treatment of upper respiratory tract diseases] // Russian Otorhinolaryngology. 2024. 23 (2). 101-110. DOI: 10.18692/1810-4800-2024-2-101-110
Review
For citations:
Antropova G.A., Egorova E.S. Topical nasal decongestants: range and application aspects. Title in english. 2024;(4(138)):595-608. (In Russ.) https://doi.org/10.34680/2076-8052.2024.4(138).595-608
Views:
30
Email this article 