Diagnostic significance of laboratory study of renin levels in blood in patients with hypertension
https://doi.org/10.34680/2076-8052.2024.2(136).265-274
Abstract
The article presents the results of studying blood renin in arterial hypertension in men and women in two age groups: young and middle-aged. Renin was determined by examination of venous blood by enzyme-linked immunosorbent assay. In a study of a group of 80 patients: 40 women and 40 men, it was found that the normorenin type of arterial hypertension predominates at young age: 95% in men and 90% in women. In the course of the study, the following feature was revealed: the incidence of high-renin arterial hypertension increases with age. In middle-aged men, high-renin arterial hypertension predominates (55%), while in middle-aged women, the normorenin type of arterial hypertension predominates (60%).
About the Authors
V. A. Pavlova
Yaroslav-the-Wise Novgorod State University
Russian Federation
Russian Federation
Veliky Novgorod
A. A. Pavlova
Yaroslav-the-Wise Novgorod State University
Russian Federation
Russian Federation
Veliky Novgorod
V. R. Weber
Yaroslav-the-Wise Novgorod State University
Russian Federation
Russian Federation
Veliky Novgorod
S. V. Zhmaylova
Yaroslav-the-Wise Novgorod State University
Russian Federation
Russian Federation
Veliky Novgorod
References
1. Nikiforova T. I., Nuvakhova M. B. Strategii povysheniya effektivnosti lecheniya patsiyentov s arterial'noy gipertoniyey [Strategies for improving the effectiveness of treatment of patients with arterial hypertension] // Russian Journal of Cardiology. 2022. 27 (S6). 66-67.
2. Sherzod B. M., Davlatshokh U. N. Effektivnost' monoterapiikandesartanom v lechenii neoslozhnennoy arterial'noy gipertenzii [Efficacy of candesartan monotherapy in the treatment of uncomplicated arterial hypertension] // Science and Education. 2023. 6. 254-262.
3. Logatkina A. V., Nikiforov V. S., Bondar S. S., Terekhov I. V., Parfenyuk V. K. Vzaimosvyaz' ekspressii retseptorov 1-go tipa k angiotenzinu II i vazoaktivnykh regulyatorov pri arterial'noy gipertenzii [Relationship between the expression of angiotensin II receptors type and vasoactive regulators in arterial hypertension] // CardioSomatica. 2020. 11 (3). 16-21. DOI: 10.26442/22217185.2020.3.200408
4. Krutikov E. S., Tsvetkov V. A., Chistyakova S. I. Vliyaniye urovnya al'doserona krovi na remodelirovaniye serdtsa i sosudov u bol'nykh sakharnym diabetom 2 tipa i arterial'noy gipertenziyey [Aldosterone blood level influence on the remodeling of heart and vessels in patients with type 2 diabetes and arterial hypertension] // Tavricheskiy medikobiologicheskiy vestnik. 2020. 3. 52-60. DOI: 10.37279/2070-8092-2020-23-3-52-60
5. Giyosova N. Vzaimodeystvie serdichesko-pochennogo kontinum v razvitiya nephropathy [Interaction of the cardio-kidney continuum in the development of nephropathy] // Oriental renaissance: Innovative, educational, natural and social sciences. 2022. 5. 597-606.
6. Maksimov M. L., Dralova O. V., Kurguzova D. O., Starodubtsev A. K., Shikaleva A. A. Lekarstvennyye sredstva, moduliruyushchiye aktivnost' renin-angiotenzinal'dosteronovoy sistemy: uchebnoye posobiye po klinicheskoy farmakologii [Medicines modulating the activity of the renin-angiotensin-aldosterone system. Textbook on clinical pharmacology]. Kazan, 2020. 160 p.
7. Redko Yu. P., Gladkikh N. N., Yagoda A. V. Remodelirovaniye levogo zheludochka u bol'nykh arterial'noy gipertenziyey s dobavochnymi pochechnymi arteriyami: assotsiatsii s urovnem renina i skorost'yu klubochkovoy fil'tratsii [Remodeling of the left ventricle in patients with arterial hypertension with additional renal arteries: associations with renin levels and glomerular filtration rate] // Lechaschi Vrach. 2019. 7. 24-27.
8. Rafael A.V., Jesús M.V., Esperanza F.B. Renin-angiotensin system: Basic and clinical aspects-A general perspective // Endocrinologia, diabetes y nutricion. 2021. 69 (1). 52-62. DOI: 10.1016/j.endien.2022.01.005
9. Elham S., Vijayvardhan K., Joshua P. et al. Highlights of mechanisms and treatment of obesity-related hypertension // Journal of human hypertension. 2020. 36 (9). 785-793. DOI: 10.1038/s41371-021-00644-y
10. Markel A. L. Genetika i patofiziologiya nizkoreninovoy arterial'noy gipertonii [Genetics and pathophysiology of low-renin arterial hypertension] // Vavilov Journal of Genetics and Breeding. 2018. 22(8). 1000-1008. DOI: 10.18699/VJ18.443
11. Filipets N. D., Ivanov D. D., Gozhenko A. I. Blokatory renin-angiotenzinal'dosteronovoy sistemy kak osnovnoye patogeneticheskoye napravleniye medikamentoznoy nefroprotektsii [Renin-angiotensin-aldosterone system blockers as the main pathogenetic approach of drug nephroprotection] // Journal of Kidney. 2019. 8 (1). 34-39. DOI: 10.22141/2307-1257.8.1.2019.157794
12. Banerjee D., Winocour P., Chowdhury T. A., De P., Wahba M., Montero R., Fogarty D., Frankel A. H., Karalliedde J., Mark P. B., Patel D. C., Pokrajac A., Sharif A., Zac-Varghese S., Bain S., Dasgupta I. Management of hypertension and renin-angiotensinaldosterone system blockade in adults with diabetic kidney disease: Association of British Clinical Diabetologists and the Renal Association UK guideline update 2021 // BMC Nephrology. 2022. 23(1). 9. DOI: 10.1186/s12882-021-02587-5
13. Moskalets O. V. Immunofermentnyy analiz v praktike klinitsista // Klinicheskiy razbor v obshchey meditsine [Enzyme immunoassay in the practice of a physician] // Clinical review for general practice. 2022. 6. 19-23. DOI: 10.47407/kr2022.3.6.00171
14. Chikhladze N. M. Chikhladze N. M. Sovremennyye tendentsii primeneniya preparatov, blokiruyushchikh renin-angiotenzinovuyu sistemu pri renovaskulyarnoy arterial'noy gipertonii [Current trends in the use of the renin-angiotensin system blocking drugs in renovascular arterial hypertension] // Systemic Hypertension. 2022. 1. 49-54. DOI: 10.38109/2075-082X-2022-1-49-54
15. Baranova E. I., Katsap A. A., Kolesnik O. S., Lebedeva E. V. Gipertonicheskaya bolezn' u zhenshchin v peri- i postmenopauze – patofiziologicheskiye mekhanizmy i podkhody k lecheniyu [Hypertension in peri- and postmenopausal women — pathophysiological mechanisms and approaches to treatment] // Russian Journal of Cardiology. 2023. 28(5). 99-107. DOI: 10.15829/1560-4071-2023-5439
16. Obertinskaya O. G. Sostoyaniye renin-al'dosteronovoy sistemy u patsiyentov s rezistentnoy arterial'noy gipertenziyey [The state of the renin-aldosterone system in patients with resistant arterial hypertension] // Zaporozhye Medical Journal. 2019. 21 (3). 290-294. DOI: 10.14739/2310-1210.2019.3.168951
17. Khlestova G. V., Nizyaeva N. V., Romanov A. Yu., Baev O. R., Ivanets T.Y u., Lapshina I. I., Mullabaeva S. M., Shuklina D. A. Dinamika izmeneniy renina, angiotenzina (1-7) i angiotenzina II pri tyazheloy i umerennoy preeklampsii // Akusherstvo i ginekologiya [The dynamics of renin, angiotensin (1-7) and angiotensin ii in severe and moderate preeclampsia] // Journal Obstetrics and Gynecology. 2019. 1. 62-66. DOI: 10.18565/aig.2019.1.62-66
18. Makarova T. P., Sadykova D. I., Melnikova Y. S. Nefrogennaya gipertenziya u detey i podrostkov [Nephrogenic hypertension in children and adolescents] // Russian Journal of Cardiology. 2019. 24. 5-6.
19. Kasaeva E. A., Mamaev S. N. Polimorfizm renin-angiotenzin-al'dosteronovoy sistemy pri khronicheskoy serdechnoy nedostatochnosti [Polymorphism of the reninangiotensin-aldosterone system in chronic heart failure] // Cardiovascular therapy and prevention. 2021. 20(1S). 40-41.
20. Povetkin S. V., Kornilov A. A. Primeneniye fiksirovannykh kombinatsiy lekarstvennykh sredstv kak sposob kompleksnoy optimizatsii antigipertenzivnoy terapii: fokus na sochetaniye amlodipina, indapamida, perindoprila [Fixed drug combinations as a way of complex antihypertensive therapy optimization: focus on the combination of amlodipine, indapamide, perindopril] // Arterial’naya Gipertenziya (Arterial Hypertension). 2022. 1. 17-26. DOI: 10.18705/1607-419X-2022-28-1-17-26
21. Vijayakumar S., Narasimman G., Huseyin C. Y., Sundararajan V. Understanding diabetes-induced cardiomyopathy from the perspective of renin angiotensin aldosterone system // Pflugers Archiv European journal of physiologi. 2021. 474 (1). 63-81. DOI: 10.1007/s00424-021-02651-x
22. Kobalava J. D., Shavarova E. K., Khomova I. A., Goreva L. A., Karapetyan L. V. Fiksirovannaya kombinatsiya amlodipina i indapamida-retard v lechenii nekontroliruyemoy arterial'noy gipertonii u lits starshe 55 let [Fixed combination of amlodipine/indapamide-retard in the treatment of uncontrolled hypertension in subjects over 55 years old] // Arterial Hypertension. 2018. 24 (5). 586-595. DOI: 10.18705/1607-419X-2018-24-5-586-595
Review
For citations:
Pavlova V.A., Pavlova A.A., Weber V.R., Zhmaylova S.V. Diagnostic significance of laboratory study of renin levels in blood in patients with hypertension. Title in english. 2024;(2(136)):265-274. (In Russ.) https://doi.org/10.34680/2076-8052.2024.2(136).265-274
Views:
44
Email this article 