Analysis of the role of the metasympathetic nervous system in non-opioid analgesia
https://doi.org/10.34680/2076-8052.2024.2(136).256-264
Abstract
The article discusses the modern possibilities of providing non-opioid analgesia in terms of the pharmacodynamics of drugs affecting different levels of analgesia using the concept of the metasympathetic nervous system role in maintaining homeostasis. When developing a hypothesis for further research, the analysis of scientific research considers the proposed options for the development of new drugs with minimal side effects for the purpose of their use in clinical pharmacology. It is substantiated that the pathological processes in the body indicated in the above analysis are significant in the formation of undesirable effects of hemodynamic changes, which is reflected in an increase in the reactivity of the cardiovascular system. A hypothesis has been put forward to continue research on the development of a new combination of drugs, including an agonist of the purinergic system and an α2-adrenergic receptor agonist for non-opioid analgesia in order to reduce the severity of their side effects, which will activate the use of such compounds in clinical pharmacology with continued research on their pharmacokinetics and pharmacodynamics in clinical practice. It is assumed that expanding the range of drugs with the ability to form compensatory reactions necessary to actualize the autoregulation of homeostasis through the activation of synaptic mechanisms that control the homeostatic potential will optimize the effectiveness of treatment, which is applicable by clinical pharmacologists in practical healthcare institutions.
About the Authors
V. V. Glushchenko
Yaroslav-the-Wise Novgorod State University
Russian Federation
Russian Federation
Veliky Novgorod
I. V. Ivanov
Yaroslav-the-Wise Novgorod State University
Russian Federation
Russian Federation
Veliky Novgorod
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Review
For citations:
Glushchenko V.V., Ivanov I.V. Analysis of the role of the metasympathetic nervous system in non-opioid analgesia. Title in english. 2024;(2(136)):256-264. (In Russ.) https://doi.org/10.34680/2076-8052.2024.2(136).256-264
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