The role of genetic polymorphisms of hemostasis factors in the pathogenesis and prognosis of sepsis (review)
https://doi.org/10.34680/2076-8052.2024.2(136).230-246
Abstract
Sepsis is a typical form of pathology, which is based on the body's reaction in the form of generalized inflammation to an infection of various nature, leading to acute multiple organ dysfunction. In sepsis, endothelial dysfunction, platelet adhesion and aggregation, hypercoagulation, hypocoagulation occur, microthrombogenesis, disturbances in the anticoagulant and fibrinolytic systems increase. Only a few studies have assessed the relationship of single nucleotide polymorphisms (SNPs) of hemostatic factors in the prognosis of sepsis: VWF, EPCR, SELP, SELE, ITGA2, ITGA2b, ITGB3, GP1BA, FGG, FGA, FII, FV, FVII, THBD, PAI-1. The disparity of the SNP results highlights the need for larger-scale studies within the framework of a personalized approach to complement the theoretical basis of the pathogenesis of sepsis, as well as to obtain new laboratory tools to improve prognostic scales, the formation of a mathematical model depending on the outcome of sepsis.
About the Authors
M. V. Osikov
South Ural State Medical University; Chelyabinsk Regional Clinical Hospital
Russian Federation
Russian Federation
Chelyabinsk
L. F. Telesheva
South Ural State Medical University
Russian Federation
Russian Federation
Chelyabinsk
A. G. Konashov
South Ural State Medical University; City Clinical Hospital No. 8
Russian Federation
Russian Federation
Chelyabinsk
A. V. Gusev
South Ural State Medical University; Chelyabinsk Regional Clinical Hospital
Russian Federation
Russian Federation
Chelyabinsk
V. A. Konashov
South Ural State Medical University; City Clinical Hospital No. 8
Russian Federation
Russian Federation
Chelyabinsk
M. A. Zotova
South Ural State Medical University
Russian Federation
Russian Federation
Chelyabinsk
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Review
For citations:
Osikov M.V., Telesheva L.F., Konashov A.G., Gusev A.V., Konashov V.A., Zotova M.A. The role of genetic polymorphisms of hemostasis factors in the pathogenesis and prognosis of sepsis (review). Title in english. 2024;(2(136)):230-246. (In Russ.) https://doi.org/10.34680/2076-8052.2024.2(136).230-246
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