Modern approaches for modeling focal ischemic stroke
https://doi.org/10.34680/2076-8052.2024.2(136).209-220
Abstract
The purpose of the authors' study is to conduct a critical analysis of data on methods for modeling ischemic stroke presented in peer-reviewed sources indexed in the Pubmed and Russian Science Citation Index databases for the 2019-2023 period. Modeling of ischemic stroke is in demand for studying pathogenesis, developing diagnostic methods and treatment. Analysis of literature data allows us to identify a number of experimental ischemic stroke models. In vitro models are represented by cellular cultures; the 3D cellular model is most preferable, since it is the closest one to the nervous tissue of the brain in its functional ability. In vivo models are most often replicated in rodents. The SHRSP rat strain is the most preferred among animal models, as it has the greatest propensity for cerebrovascular diseases, stroke in particular. The most relevant MCA model occlusion is endovascular MCA occlusion, by introducing monofilament threads into the lumen of the vessel, as it has a simple manipulation technique, a low risk of infectious complications and injuries. The embolic SMA model has a high clinical similarity to human ischemic stroke, but low resistance to the body's fibrinolytic system. Endothelin-1 and photothrombotic models are less preferred due to their technical difficulties in implementation and the low profile of studying new therapeutic options for the ischemic stroke treatment. In silico ischemic stroke modeling can serve as an alternative, since it combines risk factors for stroke, features of blood supply to the brain, cerebral metabolism and blood clot morphology.
About the Authors
M. V. Osikov
South Ural State Medical University; Chelyabinsk Regional Clinical Hospital
Russian Federation
Russian Federation
Chelyabinsk
A. V. Shelomentsev
South Ural State Medical University; Chelyabinsk Regional Clinical Therapeutic Hospital for War Veterans
Russian Federation
Russian Federation
Chelyabinsk
Yu. S. Shishkova
South Ural State Medical University
Russian Federation
Russian Federation
Chelyabinsk
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Review
For citations:
Osikov M.V., Shelomentsev A.V., Shishkova Yu.S. Modern approaches for modeling focal ischemic stroke. Title in english. 2024;(2(136)):209-220. (In Russ.) https://doi.org/10.34680/2076-8052.2024.2(136).209-220
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