COVID-19-associated diffuse alveolar lung injury in combination with diffuse b-cell lymphoma and myocardial infarction. Clinical and morphological case

Abstract

In this article, we report a case of the combination of COVID-19 with diffuse alveolar lung injury and diffuse large B-cell lymphoma with coronary artery compression by tumor nodules in the epicardium, resulting in myocardial infarction and subsequent fatal outcome. The article reviews the complex interaction between COVID-19 and oncological diseases, demonstrating how the coronavirus infection can significantly exacerbate the progression of malignant neoplasms through different mechanisms. These mechanisms include respiratory insufficiency caused by diffuse alveolar damage, systemic respiratory hypoxia, and thrombus formation, which ultimately leads to tumor tissue necrosis and the development of infarctions in various organs, particularly in the heart. Investigating such cases is important for studying intercellular interactions in the combined course of coronavirus infection and chronic diseases, and is highly indicative in the study of possible mechanisms of complications, such as myocardial infarction.