Long-term effects of prenatal use of M- and N- cholinergic drugs
https://doi.org/10.34680/2076-8052.2021.3(124).90-93
Abstract
It was found that embryonic exposure to Gangleron and Metamyzil as exogenous ligands H- and M-cholinergic receptors leads to long-term effects in the activities of central nervous system in adult young rats. It decreases learning ability in young adult rats. Cognitive functions were studied in active avoidance test. The results obtained suggest that prenatal administration of Gangleron to pregnant rats on 9-11 and 12-14 days of gestation violated the ability to acquire and reproduce active avoidance reflex in adult offspring. In the similar situation, Metamizyl has a negative effect only on ability to reproduce active avoidance reflex. Thus, the long-term negative effect of cholinotropic compounds on learning and memory abilities in young adult rats can be realized through both M- and N- cholinergic mechanisms of the developing brain.
About the Authors
E. V. Stashina
Институт экспериментальной медицины РАН
Russian Federation
Russian Federation
A. A. Bayramov
Институт экспериментальной медицины РАН;
Новгородский государственный университет имени Ярослава Мудрого
Russian Federation
Russian Federation
V. V. Glushchenko
Новгородский государственный университет имени Ярослава Мудрого
Russian Federation
Russian Federation
P. D. Shabanov
Институт экспериментальной медицины РАН;
Новгородский государственный университет имени Ярослава Мудрого
Russian Federation
Russian Federation
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Review
For citations:
Stashina E.V., Bayramov A.A., Glushchenko V.V., Shabanov P.D. Long-term effects of prenatal use of M- and N- cholinergic drugs. Title in english. 2021;(3(124)):90-93. (In Russ.) https://doi.org/10.34680/2076-8052.2021.3(124).90-93
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