Pathophysiological mechanisms and effects of ventricular-arterial uncoupling
https://doi.org/10.34680/2076-8052.2021.3(124).42-46
Abstract
The two-way interaction between the structural and functional properties of heart ventricles and the arterial bed is usually defined as ventricular-arterial coupling and it describes overall cardiovascular efficiency. Cardiovascular diseases are accompanied by changes in the rigidity and function of all parts of the circulatory system, as a result of which both primary and interdependent dysfunctions of the ventricles and arteries occur. The ratio of the “functional stiffness” of different cardiovascular regions can be expressed mathematically as the ratio between arterial elasticity (Ea) and end-systolic elasticity (Ees) of the ventricle. Non-invasive assessment of ventricular-arterial coupling describes the harmony or, conversely, the maladjustment of these parallel changes and allows the use of the ventricular-arterial coupling index in clinical risk, prognosis and treatment efficacy assessment. This review summarizes the literature on this topic, with special emphasis on the pathogenetic mechanisms underlying disorders in the structural and functional properties of the ventricles of the heart and arterial bed.
About the Author
Ye. Ye. Rumyantsev
Новгородский государственный университет имени Ярослава Мудрого
Russian Federation
Russian Federation
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Review
For citations:
Rumyantsev Ye.Ye. Pathophysiological mechanisms and effects of ventricular-arterial uncoupling. Title in english. 2021;(3(124)):42-46. (In Russ.) https://doi.org/10.34680/2076-8052.2021.3(124).42-46
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