Pathogenetic influence of stress during pregnancy on the development of obesity in offspring in experiment

In an experiment on 40 female rats of the “Wistar” line, a study was carried out of the effect of acute emotional-immobilization stress during pregnancy on the development of obesity in offspring. Experimental studies were carried out in accordance with the "Rules for conducting research using experimental animals" of the Ministry of Health of the Russian Federation. In total, 2 series of experiments were carried out. In series I, in 20 animals during pregnancy, modeling of acute emotional-immobilization stress was not performed (standard indicators). There were 134 newborns. In series II, 20 animals were modeled for acute emotional-immobilization stress during pregnancy. The number of newborns was 123. The modeling of acute emotional-immobilization stress in pregnant rats and the assessment of its pathogenetic role in the development of AO was carried out according to our methodology. It was found that immediately after giving birth and one week after that, the body weight of the offspring was significantly higher in group I, where modeling of acute emotional- immobilization stress during pregnancy was not carried out (P <0.05). It should be noted that 2 and 3 weeks after delivery, with the introduction of additional complementary foods, a more rapid increase in the body weight of the offspring was noted in group II, where acute emotional-immobilization stress was simulated during pregnancy. At the same time, the indicators in group II did not significantly exceed the indicators in group I (P> 0.05). Starting from week 4, body mass indicators in group II significantly exceeded the results in group I (P <0.05). At the same time, the differences between the study groups progressively increased. 10 weeks after giving birth, the body weight of each of the offspring in series II, where acute emotional-immobilization stress was simulated during pregnancy, exceeded those in group I by 21.3 ± 1.6%. This indicated the development of alimentary obesity in series II. Further study is needed in this direction.

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