Long-terms prenatal effects of central Mand N-holinoblockers on the motivational component of behavior in offspring of rats
https://doi.org/10.34680/2076-8052.2021.1(122).94-100
Abstract
Prenatal exposure to gangleron and, to a lesser extent, metamizil leads to significant violations of the motivational component of sexual function in sexually mature offspring of males, expressed in low values of manifestation of primary sexual activity, and an increase in approach latency and sexual dysfunction after acquiring sexual experience. Among the causes of sexual dysfunction in offspring, one can note a change in the hormonal background in male rats, in the form of a significant decrease in the level of the main androgen testosterone, as well as damage to the dopaminergic systems of the brain, manifested in a decrease in the level of dopamine.
About the Authors
E. V. Stashina
Institute of Experimental Medicine
Russian Federation
Russian Federation
Saint Petersburg
A. O. Poletaeva
Institute of Experimental Medicine
Russian Federation
Russian Federation
Saint Petersburg
A. O. Zelener
Institute of Experimental Medicine
Russian Federation
Russian Federation
Saint Petersburg
A. A. Bayramov
Institute of Experimental Medicine;
Novgorod State University
Russian Federation
Russian Federation
Saint Petersburg; Veliky Novgorod
P. D. Shabanov
Institute of Experimental Medicine
Russian Federation
Russian Federation
Saint Petersburg
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Review
For citations:
Stashina E.V., Poletaeva A.O., Zelener A.O., Bayramov A.A., Shabanov P.D. Long-terms prenatal effects of central Mand N-holinoblockers on the motivational component of behavior in offspring of rats. Title in english. 2021;(1(122)):94-100. (In Russ.) https://doi.org/10.34680/2076-8052.2021.1(122).94-100
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