Reactive changes of neurons and neuroglia cells in mesolymbic cerebral structures at perinatal exposure to morphine in rats
https://doi.org/10.34680/2076-8052.2021.1(122).24-27
Abstract
In order to elucidate changes in the number and morphometric parameters of neurons and neuroglial cells in the mesolimbic dopaminergic system of the brain (MDS), dopamine deficiency in the centers of which is considered to be the main prerequisite for the formation of addictions, 0.1 mg of opiates were administered during preand postnatal exposure to this system. 1% solution of morphine hydrochloride inside the amnion of fetuses of female Wistar rats (n = 5) on the 17th day after fertilization and intraperitoneally to rat pups on the 4th day after birth (n = 5). It was found that the perinatal effect of morphine on MDS in rats causes atrophic changes, swelling and death of some neurons, a decrease in the volume and shrinkage of the remaining unchanged neurons. Damage to neurons, more pronounced during prenatal exposure, is accompanied by an increase in the number of microglia cells and their phagocytic activity. Morphine exposure does not change the number of satellite macrogliocytes and the average distance between them and the bodies of viable neurons.
About the Authors
A. V. Droblenkov
Saint-Petersburg Medico-Social Institute;
Institute of Experimental Medicine;
Novgorod State University
Russian Federation
Russian Federation
Saint Petersburg; Veliky Novgorod
E. Yu. Pankrashоva
Institute of Experimental Medicine;
Astrakhan State Medical University
Russian Federation
Russian Federation
Saint Petersburg; Astrakhan
A. V. Fedorov
Saint-Petersburg Medico-Social Institute
Russian Federation
Russian Federation
Saint Petersburg
N. A. Popkovsky
Saint-Petersburg Medico-Social Institute;
Institute of Experimental Medicine
Russian Federation
Russian Federation
Saint Petersburg
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Review
For citations:
Droblenkov A.V., Pankrashоva E.Yu., Fedorov A.V., Popkovsky N.A. Reactive changes of neurons and neuroglia cells in mesolymbic cerebral structures at perinatal exposure to morphine in rats. Title in english. 2021;(1(122)):24-27. (In Russ.) https://doi.org/10.34680/2076-8052.2021.1(122).24-27
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