Molecular genetic changes in appendix of the children with COVID-19
https://doi.org//10.34680/2076-8052.2021.1(122).62-66
Abstract
The rapid dissemination of SARS-CoV-2 has resulted in over 54 million infections and about 1,3 million deaths. SARS-CoV-2 can damage the kidneys, heart, intestines, lungs and other organs. The question of the effect of SARS-CoV-2 on the mucous membrane of the appendix in children remains open. The aim of the study was to assess the molecular genetic profile of cytological processes in the tissue of the appendix in the children with COVID-19. Fragments of the appendix of the children with confirmed COVID-19 (n = 24) were studied by real-time polymerase chain reaction to determine the expression of SARS-CoV-2 RNA and genes encoding protein complexes: ACE-2 and Furin. In patients affected by COVID-19, the presence of coronavirus genetic material in the appendix was recorded. Increased expression of ACE-2 and Furin was found in the tissue, what determines favorable conditions for coronavirus defeat. Based on the results of RT-PCR for SARS-CoV-2 and the expression of ACE-2 and Furin, we can talk about the viral load in the appendix in children.
About the Authors
G. A. Demyashkin
I.M. Sechenov First Moscow State Medical University (Sechenovskiy University);
National Medical Research Radiological Centre
Russian Federation
Russian Federation
Moscow; Obninsk
A. Yu. Tsibulevskiy
Medical University "Reaviz"
Russian Federation
Russian Federation
Moscow
K. R. Gorokhov
National Medical Research Radiological Centre
Russian Federation
Russian Federation
Obninsk
P. V. Nikitin
P.K. Anokhin Research Institute of Normal Physiology
Russian Federation
Russian Federation
Moscow
I. A. Zorin
I.M. Sechenov First Moscow State Medical University (Sechenovskiy University)
Russian Federation
Russian Federation
Moscow
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Review
For citations:
Demyashkin G.A., Tsibulevskiy A.Yu., Gorokhov K.R., Nikitin P.V., Zorin I.A. Molecular genetic changes in appendix of the children with COVID-19. Title in english. 2021;(1(122)):62-66. (In Russ.) https://doi.org//10.34680/2076-8052.2021.1(122).62-66
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