Pathogenetic substantiation of the development of neurointoxication after psychological correction

Based on the fundamental principles of the principle of dominance by A.A.Ukhtomsky, the theory of functional systems by P.K. Anokhin, studies on the general adaptive syndrome of G. Selye, taking into account the peculiarities of the reaction of the human body to the effects of psychological stressors, as well as the results of our own studies, methods for assessing endogenous intoxication after psychological interventions, protected by RF patents for inventions, a pathogenetic substantiation of the development of neurotoxicosis after psychological correction of previously experienced stressful situations was carried out. For a modern lifestyle, the priority reaction to the influence of a psychological stressor has become the strategy of ‘fading’, characterized by suppression of emotional arousal and a cognitive assessment of the situation and various possible scenarios of its development, often in a negative context. Against the background of activation of the sympathoadrenal system and suppression of emotional excitement, in conditions of peripheral vasospasm at the organism level, anaerobic catabolism becomes a priority, with the formation of neurotoxins, some of which are deposited in the body. At the same time, in the central nervous system, against the background of continuous exposure to psychological stressors leading to psychological trauma, a stagnant suppressed focus of excitation is formed, which has a negative effect on the behavioral and physiological patterns of response to the stimulus. During the psychological correction of post-traumatic stress disorder, accompanied by an intense emotional reaction, a stagnant focus of excitation is activated, which plays the role of a trigger for the reaction in the “fight-flight” format at the body level. In turn, this leads to activation and release of neurotoxins from the depot, which in the post-correction period are accompanied by phenomena of endogenous intoxication, including neurointoxication. Further research is needed in this direction.

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