Content of some vitamins in patients with post-COVID syndrome
https://doi.org/10.34680/2076-8052.2022.2(127).80-84
Abstract
Vitamins C and A have an immunostimulating effect, and their deficiency leads to an increased risk of developing viral infections. Numerous studies have indicated that the administration of vitamins can decrease the risk and severity of viral infections. The data obtained have stimulated an interest in the efficacy of these vitamins in people with a new coronavirus (SARS-CoV-2) infection. The article aims to evaluate the content of vitamins A, C, as well as peroxidation activity in the blood serum of patients with post-COVID syndrome. For the analysis, 30 patients aged 43 to 63 years were randomly selected, and 2 groups were formed. Group 1 included 12 patients with post-COVID syndrome, who have had a severe disease requiring hospitalization. Group 2 included 18 patients who did not have the new coronovirus infection but complained of physical and mental fatigue, muscle weakness. The serum levels of vitamin A, C and malondialdehyde were measured. Vitamin C content was determined in urine samples. It has been found that patients with postCOVID syndrome demonstrate significant changes in vitamin A and C levels, which trigger the processes that result in oxidative stress.
About the Authors
T. I. Okonenko
Новгородский государственный университет имени Ярослава Мудрого
Russian Federation
Russian Federation
G. A. Antropova
Новгородский государственный университет имени Ярослава Мудрого
Russian Federation
Russian Federation
E. S. Egorova
Новгородский государственный университет имени Ярослава Мудрого
Russian Federation
Russian Federation
References
1. Manion M., Hullsiek K.H., Wilson E.M.P., et al. Vitamin D deficiency is associated with IL-6 levels and monocyte activation in HIV-infected persons. PLOS ONE, 2017, vol. 12(5), art. no. e0175517. doi: https://doi.org/10.1371/journal.pone.0175517
2. Allard J.P., Aghdassi E., Chau J., et al. Effects of vitamin E and C supplementation on oxidative stress and viral load in HIV-infected subjects. AIDS, 1998, vol. 12(13), pp. 1653– 1659. doi: https://doi.org/10.1097/00002030-19981300000013
3. Kodencova V.M., Vrzhesinskaya O.A., Risnik D.V., Nikityuk D.B., Tutel'yan V.A. Obespechennost' naseleniya Rossii mikronutrientami i vozmozhnosti ee korrekcii Sostoyanie problemy [Micronutrient status of population of the Russian Federation and possibility of its correction. State of the problem]. Voprosy pitaniya — Problems of Nutrition, 2017, vol. 86, no. 4, pp. 113–124. doi: https://doi.org/10.24411/00428833-2017-00067
4. Karonova T.L., Grineva E.N., Nikitina I.L., Cvetkova E.V., Todieva A.M., Belyaeva O.D., et al. Rasprostranennost' deficita vitamina D v severo-zapadnom regione RF sredi zhitelej g. Sankt-Peterburga i g. Petrozavodska [The prevalence of vitamin D deficiency in the northwestern region of the Russian Federation among the residents of St. Petersburg and Рetrozavodsk]. Osteoporoz i osteopatii — Osteoporosis and Osteopathy, 2013, vol. 16, no. 3, pp. 3–7. doi: https://doi.org/10.14341/osteo201333-7
5. Giménez, V.M.M., Sanz R.L.; Marón F.J.M., et al. Vitamin D-RAAS Connection: An Integrative Standpoint into Cardiovascular and Neuroinflammatory Disorders. Curr. Protein. Pept. Sci., 2020, vol. 21(10), pp. 948–954. doi: 10.2174/1389203721666200606220719
6. Kinash M.I., Boyarchuk O.R. Zhirorastvorimye vitaminy i immunodeficitnye sostoyaniya: mekhanizmy vliyaniya i vozmozhnosti ispol'zovaniya [Fat-soluble vitamins and immunodeficiency: mechanisms of influence and opportunities for use]. Voprosy pitaniia — Problems of Nutrition, 2020, vol. 89, no. 3, pp. 22–32. doi: https://doi.org/10.24411/0042-8833-2020-10026
7. Semba R. D. Vitamin A and immunity to viral, bacterial and protozoan infections. Proc. Nutr. Soc., 1999, vol. 58(3), pp. 719–727. doi: https://doi.org/10.1017/S0029665199000944
8. Beigmohammadi, M.T., Bitarafan S., Hoseindokht A., et al. The effect of supplementation with vitamins A, B, C, D, and E on disease severity and inflammatory responses in patients with COVID-19: a randomized clinical trial. Trials, 2021, vol. 22(1), art. no. 802. doi: https://doi.org/10.1186/s13063021-05795-4
9. Bae M., Kim H. Mini-Review on the Roles of Vitamin C, Vitamin D, and Selenium in the Immune System against COVID-19. Molecules, 2020, vol. 25(22), art. no. 5346. doi: https://doi.org/10.3390/molecules25225346
10. Lordan R., Rando H.M. COVID-19 Review Consortium, Greene CS. Dietary supplements and nutraceuticals under investigation for COVID-19 prevention and treatment. mSystems, 2021, vol. 6, no. 3, art. no. e00122-21. doi: https://doi.org/10.1128/mSystems.00122-21
11. Moreira A., Kekkonen R., Delgado L., et al. Nutritional modulation of exercise-induced immunodepression in athletes: a systematic review and meta-analysis. Eur J Clin Nutr., 2007, vol. 61, pp. 443–460. doi: https://doi.org/10.1038/sj.ejcn.1602549
12. Savchenko A.A., Anisimova E.N., Borisov A.G., Kondakov A.E. Vitaminy kak osnova immunometabolicheskoi terapii [Vitamins as the Basis of Immunometabolic Therapy]. Krasnoyarsk, KrasGMU Publ., 2011. 213 p.
13. Stal'naya I.D., Garishvili G.G. Sovremennye metody v biohimii [Modern methods in biochemistry]. Moscow: Medicina Publ., 1977. 240 p.
14. Baryshnikova G.A., Chorbinskaya S.A., Zimina T.A., Stepanova I.I., Kudryavceva N.A. COVID-19: mesto korrektorov metabolizma v terapii bol'nyh s postkovidnym sindromom [COVID-19: the place of metabolic correctors in the therapy of patients with post-COVID syndrome]. Lechashchij vrach — Attending Physician Journal, 2022, vol. 25, no. 3, pp. 80–86. doi: https://doi.org/10.51793/OS.2022.25.3.013
15. Barazzoni R., Bischoff S.C., Breda J., et al. ESPEN expert statements and practical guidance for nutritional management of individuals with SARS-CoV-2 infection. Clin.l Nutrition, 2020, vol. 39(6), pp. 1631–1638. doi: https://doi.org/10.1016/j.clnu.2020.03.022
16. Fernandes S.L., Ferreira A.L. dos A., Soriano E. de A., et al. The role of micronutrients on COVID-19 treatment for adults, children and elderly. Research, Society and Development, 2021, vol. 10, no. 2. e7010212259. doi: 10.33448/rsd-v10i2.12259
17. Arvinte C., Singh M., Marik P.E. Serum levels of vitamin C and vitamin D in a cohort of critically ill COVID-19 patients of a North American community hospital intensive care unit in May 2020: a pilot study. Med Drug Discov., 2020, vol. 8, art. no. 100064. doi: https://doi.org/10.1016/j.medidd.2020.100064
18. Tyml K. Vitamin C and Microvascular Dysfunction in Systemic Inflammation. Antioxidants (Basel, Switzerland), 2017, vol. 6, no 3, art. no. 49. doi:10.3390/antiox6030049
19. Hiedra R., Lo K.B., Elbashabsheh M., et al. The use of IV vitamin C for patients with COVID-19: a case series. Expert Rev Anti Infect Ther., 2020, vol. 18, no. 12, pp. 1259–1261. doi: https://doi.org/10.1080/14787210.2020.1794819
20. Marik P.E., Khangoora V., Rivera R., et al. Hydrocortisone, vitamin C, and thiamine for the treatment of severe sepsis and septic shock: A retrospective beforeafter study. Chest., 2017, vol. 151(6), pp. 1229–1238. doi: https://doi.org/10.1016/j.chest.2016.11.036
21. Fowler A.A., Truwit J.D., Hite R.D., et al. Effect of vitamin C infusion on organ failure and biomarkers of inflammation and vascular injury in patients with sepsis and severe acute respiratory failure: The CITRIS-ALI Randomized Clinical Trial. JAMA, 2019, vol. 322(13), pp. 1261-1270. doi: https://doi.org/10.1001/jama.2019.11825
22. Pisoschi A.M., Pop A., Iordache F. et al. Antioxidant, anti-inflammatory and immunomodulatory roles of vitamins in COVID-19 therapy. Eur. J. Med. Chem., 2022, vol. 232, аrticle number: 114175. doi: https://doi.org/10.1016/j.ejmech.2022.114175
23. Okonenko T.I., Antropova G.A., Egorova E.S. Sovremennye podhody k vyboru vitaminno-mineral'nyh kompleksov v rabote aptechnogo specialista [Current approaches to the choice of vitamin and mineral supplements by a pharmacy professional]. Vestnik Novgorodskogo gosudarstvennogo universiteta. Ser.: Meditsinskiye nauki – Vestnik NovSU. Issue: Medical Sciences, 2020, no. 1(117), pp. 90-94.
Review
For citations:
Okonenko T.I., Antropova G.A., Egorova E.S. Content of some vitamins in patients with post-COVID syndrome. Title in english. 2022;(2(127)):80-84. (In Russ.) https://doi.org/10.34680/2076-8052.2022.2(127).80-84
Views:
67
Email this article 