Bactericidal properties of amber and succinic acid in relation to staphylococcus aureus
https://doi.org/10.34680/2076-8052.2022.2(127).69-75
Abstract
The purpose of this work was to study the antimicrobial properties of untreated Baltic amber and succinic acid in relation to S. aureus. The antimicrobial activity of alcohol and acetone extracts from untreated amber and an aqueous solution of succinic acid was revealed against such clinical isolates of Staphylococcus aureus as: BS-1, BS-9, BS-12, BS-19, isolated from hospitalized patients (MIC — from 2500 µg/ml to 5000 µg/ml) and a reference strain from the American type culture collection S. aureus ATCC 29213 (MIC — 2500 µg/ml). In experimental modeling of intestinal staphylococcal infection in mice, a positive effect of succinic acid on the clinical isolate of S. aureus (BS-9) was established. The amount of S. aureus in the intestinal content decreased in all experimental animals (2.35×104) compared to positive control animals (8.58×105). The minimum inhibitory concentration of an aqueous solution of succinic acid in relation to S. aureus corresponds to the value of 2.5 mg/ml.
About the Authors
E. I. Degtyareva
Гомельский государственный медицинский университет
Belarus
Belarus
T. A. Petrovskaya
Гомельский государственный медицинский университет
Belarus
Belarus
N. N. Veyalkina
Институт радиобиологии НАН Беларуси
Belarus
Belarus
N. A. Lebedev
Мозырский государственный педагогический университет им. И.П. Шамякина
Belarus
Belarus
A. N. Lebedev
Гомельский государственный медицинский университет
Belarus
Belarus
D. D. Zinkevich
Гомельский государственный медицинский университет
Belarus
Belarus
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Review
For citations:
Degtyareva E.I., Petrovskaya T.A., Veyalkina N.N., Lebedev N.A., Lebedev A.N., Zinkevich D.D. Bactericidal properties of amber and succinic acid in relation to staphylococcus aureus. Title in english. 2022;(2(127)):69-75. (In Russ.) https://doi.org/10.34680/2076-8052.2022.2(127).69-75
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