Analysis of medical and social factors influencing incidence and development of severe COVID-19 in patients with HIV
https://doi.org/10.34680/2076-8052.2022.2(127).55-59
Abstract
The article examines the factors influencing the incidence and development of a severe course of a new coronavirus infection (COVID-19) in HIV-infected patients. The study included all co-infected patients (n=68) who received inpatient care for COVID-19 in various medical institutions of the Novgorod region in the period from January 1, 2020 to December 31, 2021. The results of the study showed that COVID-19 infection was more often registered in HIV-infected patients with a long history of HIV infection (5 years or more) and not taking antiretroviral drugs. COVID-19 in HIV-infected patients was more often in the moderate form of the disease (77.9%). Factors aggravating the severity of COVID-19 in HIV-infected patients are signs of progression of HIV infection (the level of CD4lymphocytes is less than 200 cells/µl; the viral load is more than 100,000 cop/ml) and the absence of antiretroviral therapy. Comorbid pathology (the presence of opportunistic infections and concomitant diseases) is a trigger factor in the development of severe forms of COVID-19 and adverse outcomes.
About the Authors
O. V. Azovtseva
Новгородский государственный университет имени Ярослава Мудрого
Russian Federation
Russian Federation
A. A. Markova
Новгородский государственный университет имени Ярослава Мудрого
Russian Federation
Russian Federation
I. D. Dmitrieva
Новгородский государственный университет имени Ярослава Мудрого
Russian Federation
Russian Federation
References
1. Karmen-Tuohy S., Carlucci P.M., Zervou F.N., Zacharioudakis I.M., Rebick G., Klein E., Reich J., Jones S., Rahimian J. Outcomes among HIV-positive patients hospitalized with COVID-19. J. Acquir. Immune Defic. Syndr., 2020, vol. 85(1), pp. 6–10. doi: 10.1097/QAI.0000000000002423
2. Patel R.H., Pella P.M. COVID-19 in a patient with HIV infection. J. Med. Virol., 2020, vol. 92(11), pp. 2356–2357. doi: 10.1002/jmv.26049
3. Boffito M., Waters L. More evidence for worse COVID-19 outcomes in people with HIV. The Lancet HIV, 2021, vol. 8(11), pp. e661–e662. doi:10.1016/S2352-3018(21)00272-1
4. Mellor M.M., Bast A.C., Jones N.R., Roberts N.W., Ordóñez-Mena J.M., Reith A.J.M., Butler C.C., Matthews P.C., Dorward J. Risk of adverse coronavirus disease 2019 outcomes for people living with HIV. AIDS, 2021, vol. 35, iss. 4, pp. F1–F10. doi: 10.1097/QAD.0000000000002836
5. Tesoriero J.M., Swain C.E., Pierce J.L., et al. COVID-19 Outcomes Among Persons Living with or without Diagnosed HIV Infection in New York State. JAMA Netw Open., 2021, vol. 4(2), art. no. e2037069. doi: 10.1001/jamanetworkopen.2020.37069
6. Hoffmann C., Casado J.L., Härter G., Zamboni L., Wu M., Holtgrave D.R., Gonzalez C.J., Udo T., Morne J.E., HartMalloy R., Rajulu D.T., Leung S.J., Rosenberg E.S. Immune deficiency is a risk factor for severe COVID-19 in people living with HIV. HIV Med., 2021, vol. 22(5), pp. 372–378. doi: 10.1111/hiv.13037
7. COVID-19 & HIV. Available at: https://www.eacsociety.org/home/covid-19-and-hiv.html
8. Benkovic S., Kim M., Sin E. Four cases: Human immunodeficiency virus and novel coronavirus 2019 Coinfection in patients from Long Island. J. Med. Virol., 2020, vol. 92(11), pp. 2338–2340. doi: 10.1002/jmv.26029
9. Pokrovsky V.V., Yurin O.G., Kravchenko A.V., Belyaeva V.V., Ermak T.N., Kanestri V.G., Shakhgildyan V.I., Kozyrina N.V., Buravtsova V.V., Narsia R.S., Pokrovskaya A.V., Efremova O.S., Konnov V.V., Kuimova U.A., Popova A.A., Khokhlova O.N., Voronin E.E., Afonina L.Yu., Vasilyeva I.A., Zimina V.N. Natsional'nyye rekomendatsii po dispansernomu nablyudeniyu i lecheniyu VICH-infektsiyey. Klinicheskiy protokol. Epidemiologiya i infektsionnyye bolezni [National recommendations for dispensary monitoring and treatment of HIV infection. Clinical protocol. Epidemiology and infectious diseases]. Aktualnyye voprosy — Current Issues, 2016, vol. 6 (appendix). 120 p.
10. Belyakov N.A., Rassokhin V.V., Trofimova T.N., Stepanova E.V., Panteleev A.M., Leonova O.N., Buzunova S.A., Konovalova N.V., Milichkina A.M., Totolya A.A. Komorbidnyye i tyazhelyye formy VICH-infektsii [Comorbid and severe forms of HIV infection]. VICHinfektsiya i immunosupressii — HIV Infection and Immunosuppression, 2016, vol. 8, no.3, p.9-25. doi: https://doi.org/10.22328/2077-9828-2016-8-3-9-25
11. Belyakov N.A., Rassokhin V.V. Komorbidnyye sostoyaniya pri VICH-infektsii. Ch. II. Vtorichnyye i sopustvuyushchiye infektsii [Comorbid conditions in HIV infection. P.II. Secondary and concomitant infections]. St. Petersburg, Baltiyskiy meditsinskiy obrazovatel'nyy tsentr Publ., 2019. 252 p.
12. Leonova O.N., Stepanova E.V., Belyakov N.A. Tyazhelyye i komorbidnyye sostoyaniya u bol'nykh s VICH-infektsiyey: analiz neblagopriyatnykh iskhodov [Severe and comorbid conditions in patients with HIV infection: Analysis of adverse outcomes]. VICH-infektsiya i immunosupressii — HIV Infection and Immunosuppression, 2017, vol. 9, no. 1, pp. 55– 64. doi: https://doi.org/10.22328/2077-9828-2017-9-1-55-64
13. Azovtseva O.V. Bogacheva T.E., Weber V.R., Arkhipov G.S. Analiz osnovnykh prichin letal'nykh iskhodov u VICHinfitsirovannykh bol'nykh [Analysis of the main causes of deaths in HIV-infected patients]. VICH-infektsiya i immunosupressii — HIV Infection and Immunosuppression, 2018, vol. 10, no. 1, pp. 84–91. doi: https://doi.org/10.22328/2077-9828-2018-10-1-84-91
Review
For citations:
Azovtseva O.V., Markova A.A., Dmitrieva I.D. Analysis of medical and social factors influencing incidence and development of severe COVID-19 in patients with HIV. Title in english. 2022;(2(127)):55-59. (In Russ.) https://doi.org/10.34680/2076-8052.2022.2(127).55-59
Views:
56
Email this article 