Morphological changes in the liver on the administration of doxorubicin in experimental animals
https://doi.org/10.34680/2076-8052.2022.2(127).51-54
Abstract
The high prevalence of using chemotherapeutic drugs requires studying the mechanisms of their effect. This article discusses some of the mechanisms of the pro-apoptotic effect of doxorubicin on the liver in experimental animals. A number of patterns of structural morphological responses have been identified. As the object of the study, white outbred mice formed according to the principle of pairs of analogues were used, with the formation of two experimental groups and one control group. On day 14, the animals were withdrawn from the experiment, followed by a visual assessment of the abdominal organs and the microscopic organization of the liver. As a result, a macroscopic examination revealed a pronounced reaction with the formation of aseptic peritonitis and the development of rather gross functional changes in the unpaired abdominal organs of the abdominal cavity. Microscopic examination revealed non-specific types of responses to the administration of doxorubicin with the formation of leukocyte infiltration in various parts of the liver and hepatic lobules, the accumulation of fatty inclusions in the cytoplasm of hepatocytes. Also, there are pronounced differences in responses among individuals of different sexes to the injection of an equal amount of doxorubicin. The severity of responses to the drug administration also had a dose-dependent effect.
About the Authors
A. A. Yakovlev
Ижевская государственная медицинская академия
Russian Federation
Russian Federation
Yu. G. Vasiliev
Ижевская государственная сельскохозяйственная академия
Russian Federation
Russian Federation
G. V. Shumikhina
Ижевская государственная медицинская академия
Russian Federation
Russian Federation
D. S. Berestov
Ижевская государственная сельскохозяйственная академия
Russian Federation
Russian Federation
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For citations:
Yakovlev A.A., Vasiliev Yu.G., Shumikhina G.V., Berestov D.S. Morphological changes in the liver on the administration of doxorubicin in experimental animals. Title in english. 2022;(2(127)):51-54. (In Russ.) https://doi.org/10.34680/2076-8052.2022.2(127).51-54
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