Cancer-associated fibroblasts forming tissue microenvironment and drug resistance of nonsmall cell lung cancer
https://doi.org/10.34680/2076-8052.2022.2(127).47-50
Abstract
The article is devoted to the role of tumor-associated fibroblasts in the development of non-small cell lung cancer. Their main properties are considered in comparison with normal fibroblasts. Characteristic markers are given, which can be used to judge whether tumor-associated fibroblasts belong to different sources of origin (resident and recruited). The patterns of transformation and activation, proand anti-tumor interactions in the tissue microenvironment of the tumor are ызусшашув. The main known mechanisms of the influence of tumor-associated fibroblasts on the formation of drug resistance in non-small cell lung cancer are described: stimulation of epithelialmesenchymal transformation, compaction of extracellular matrix proteins, hypoxic signaling, maintaining stemness of cancer cells.
About the Author
Ye. Ye. Rumyantsev
Новгородский государственный университет имени Ярослава Мудрого
Russian Federation
Russian Federation
References
1. Chen C., et al. Role of cancer-associated fibroblasts in the resistance to antitumor therapy, and their potential therapeutic mechanisms in non-small cell lung cancer. Oncology Letters, 2021, vol. 21, no. 5, pp. 1–12.
2. Ballester B., Milara J., Cortijo J. Idiopathic pulmonary fibrosis and lung cancer: mechanisms and molecular targets. International journal of molecular sciences, 2019, vol. 20, no. 3, p. 593.
3. Liu T., et al. Cancer-associated fibroblasts: an emerging target of anti-cancer immunotherapy. Journal of Hematology & Oncology, 2019, vol. 12, no. 1, pp. 1–15.
4. Cabral-Pacheco G. A., et al. The roles of matrix metalloproteinases and their inhibitors in human diseases. International Journal of Molecular Sciences, 2020, vol. 21, no. 24, p. 9739.
5. Kalluri R. The biology and function of fibroblasts in cancer. Nature Reviews Cancer, 2016, vol. 16, vol. 9, pp. 582–598.
6. Chen X., Song E. Turning foes to friends: targeting cancerassociated fibroblasts. Nature reviews. Drug discovery, 2019, vol. 18, no. 2, pp. 99–115.
7. Kobayashi H. et al. Cancer-associated fibroblasts in gastrointestinal cancer. Nature reviews Gastroenterology & Hepatology, 2019, vol. 16, no. 5, pp. 282–295.
8. Mitchell M. I., Engelbrecht A. M. Metabolic hijacking: A survival strategy cancer cells exploit? Critical reviews in Oncology/Hematology, 2017, vol. 109, pp. 1–8.
9. Joyce J. A., Fearon D. T. T cell exclusion, immune privilege, and the tumor microenvironment. Science, 2015, vol. 348, no. 6230, pp. 74–80.
10. Acerbi I. et al. Human breast cancer invasion and aggression correlates with ECM stiffening and immune cell infiltration. Integrative Biology, 2015, vol. 7, no. 10, pp. 1120–1134.
11. Ying L., et al. Cancer associated fibroblast-derived hepatocyte growth factor inhibits the paclitaxel-induced apoptosis of lung cancer A549 cells by up-regulating the PI3K/Akt and GRP78 signaling on a microfluidic platform. PloS one, 2015, vol. 10, no. 6, p. e0129593.
12. Su S., et al. CD10+ GPR77+ cancer-associated fibroblasts promote cancer formation and chemoresistance by sustaining cancer stemness. Cell, 2018, vol. 172, no. 4, pp. 841–856. e16.
13. Navab R., et al. Integrin α11β1 regulates cancer stromal stiffness and promotes tumorigenicity and metastasis in nonsmall cell lung cancer. Oncogene, 2016, vol. 35, no. 15, pp. 1899–1908.
14. Petrova V., et al. The hypoxic tumour microenvironment. Oncogenesis, 2018, vol. 7, no. 1, pp. 1–13.
Review
For citations:
Rumyantsev Ye.Ye. Cancer-associated fibroblasts forming tissue microenvironment and drug resistance of nonsmall cell lung cancer. Title in english. 2022;(2(127)):47-50. (In Russ.) https://doi.org/10.34680/2076-8052.2022.2(127).47-50
Views:
37
Email this article 