Ultramicroscopic features of the structure of thyroid gland C cells in rats after 60 days of sodium benzoate exposure
https://doi.org/10.34680/2076-8052.2022.2(127).43-46
Abstract
To achieve the aim of the study, 12 white mature male rats were selected and divided into two groups: the group I consisted of animals treated daily for 60 days intragastrically with sodium benzoate at a dose of 1000 mg/kg of body weight, and the group II are control animals. Samples of thyroid gland were taken for electron microscopy, processed, sectioned, and stained according to a standard protocol. In animals of the group I, large-sized secretory granules prevailed in the cytoplasm of C cells, some of them had low electron density, some had heterogeneous content, while others remained electron-dense. The nuclei of parafollicular cells had a narrow rim of heterochromatin under the karyolemma. Most of the mitochondria showed irregularly shaped cristae. In addition, local mitochondrial damage was also present. Short and thin cisterns of the rough endoplasmic reticulum with a small number of ribosomes on their outer surface were found. The above morphological features of the thyroid gland C cells in mature rats indicate a change in the mechanisms of calcitonin synthesis in the cisterns of the endoplasmic reticulum, the protein-synthetic function of cells and its energy supply under the influence of sodium benzoate.
About the Authors
V. N. Morozov
Белгородский государственный национальный исследовательский университет
Russian Federation
Russian Federation
E. N. Morozova
Белгородский государственный национальный исследовательский университет
Russian Federation
Russian Federation
A. V. Solin
Белгородский государственный национальный исследовательский университет
Russian Federation
Russian Federation
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For citations:
Morozov V.N., Morozova E.N., Solin A.V. Ultramicroscopic features of the structure of thyroid gland C cells in rats after 60 days of sodium benzoate exposure. Title in english. 2022;(2(127)):43-46. (In Russ.) https://doi.org/10.34680/2076-8052.2022.2(127).43-46
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