Changes in the composition of the microbiota as a predictor of the development of bloodstream infections in hemoblastosis
https://doi.org/10.34680/2076-8052.2022.4(129).84-86
Abstract
Multiple myeloma (MM) accounts for about 1% of oncological diseases and more than 10% of the total number of hemoblastoses. High-dose chemotherapy followed by autologous hematopoietic stem cell transplantation (autoHSCT) is the standard treatment. An essential role in the development of bloodstream infections in hematological malignancies and, particularly, in MM is played by endogenous infection of the blood through the intestines. The leading factor contributing to the occurrence of microbiome disorders is antibacterial therapy. The emergence of new drugs such as proteasome inhibitors and monoclonal antibodies did not rule out autoHSCT and retained its importance in the treatment of patients. The aim of our study was to investigate changes in the gut microbiome before and after autoHSCT in patients with MM.
About the Authors
A. V. Kuleshova
Российский научно-исследовательский институт гематологии и трансфузиологии Федерального медико-биологического агентства
Russian Federation
Russian Federation
V. N. Chebotkevich
Российский научно-исследовательский институт гематологии и трансфузиологии Федерального медико-биологического агентства
Russian Federation
Russian Federation
References
1. Bessmeltsev S.S., Abdulkadyrov K.M. Mnozhestvennaya miyeloma: rukovodstvo dlya vrachey [Multiple myeloma: a guide for physicians]. Moscow, Spetsial'noye izdatel'stvo meditsinskikh knig Publ., 2016. 504 p.
2. Chebotkevich V.N., Kuleshova A.V., Kiseleva E.E., Bessmeltsev S.S. Mikrobiom cheloveka i yego rol' v gemopoeze i v razvitii mnozhestvennoy miyelomy [Human microbiome and its role in hematopoiesis and in the development of multiple myeloma]. Vestnik gematologii — Bulletin of Hematology, 2021, vol.XVII, no.3, pp.4–10.
3. Roma Al Hamed, A., et al. Current status of autologous stem cell transplantation for multiple myeloma. Blood Cancer J., 2019, vol.9, no.4, p.44. doi: https://doi.org/10.1038/s41408-019-0205-209
4. Anisimova N. Yu. Immunological pathogenesis of sepsis and use of hemosorption for treatment of cancer patients with sepsis. New York, Nova Science Publishers Inc., 2014, pp.57–114.
5. Niyazmatov A.A., Grigoryants R.G., Samsonova N.N. Vyyavleniye endotoksina gramotritsatel'nykh bakteriy s pomoshch'yu diagnosticheskikh naborov «MACH-endotox spp» v komponentakh donorskoy krovi i yego sravneniye s urovnem interleykinov [Detection of endotoxin of gramnegative bacteria using diagnostic kits «MACH-endotox spp.» in components of the donor blood and its comparison with the level of interleukins]. Byulleten' NTSSSKH im. A.N. Bakuleva RAMN «Serdechno-sosudistyye zabolevaniya» — The Bulletin of Bakoulev Center. Cardiovascular Diseases, 2011, vol.12, no.6, pp.79–83.
6. Chebotkevich V.N., Kovalev A.A., Stoma I.O. Izmeneniya mikrobioma kishechnika u patsiyentov s mnozhestvennoy miyelomoy pri autologichnoy transplantatsii gemopoeticheskikh stvolovykh kletok [Changes in the gut microbiome in patients with multiple myeloma after autologous hematopoietic stem cell transplantation]. Vestnik gematologii — Bulletin of Hematology, 2022, vol.18, no.1, pp.4–7.
7. Chebotkevich V.N., Martens E.A., Sidorenko S.V., et al. Uskorennyy metod identifikatsii bakteriy i mikromitsetov v gemokul'turakh u detey s ispol'zovaniyem mul'tipleksnoy PTSR v rezhime real'nogo vremeni [Accelerated method for identification of bacteria and micromycetes in blood cultures in children using multiplex real-time PCR]. Zhurnal infektologii — Journal Infectology, 2019, vol.11, no.4, pp.107–112. doi: https://doi.org/10.22625/2072-6732-2019-11-4-107-112.
Review
For citations:
Kuleshova A.V., Chebotkevich V.N. Changes in the composition of the microbiota as a predictor of the development of bloodstream infections in hemoblastosis. Title in english. 2022;(4(129)):84-86. (In Russ.) https://doi.org/10.34680/2076-8052.2022.4(129).84-86
Views:
45
Email this article 