Studying the interaction of chloramphenicol with maleic anhydride copolymer and polyvinylpyridines
https://doi.org/10.34680/2076-8052.2021.4(125).83-86
Abstract
The change in the absorption of chloramphenicol in the presence of poly(vinylpyridines) and/or poly(maleic anhydride-со-vinyl acetate) in water-ethanol solutions has been studied. It has been found that the equimolar addition of poly(4-vinylpyridine) increases chloramphenicol absorption while the maleic anhydride copolymer does not affect it. Changes in the spectra of ternary mixtures of chloramphenicol copolymer: poly (vinylpyridine), have been shown, analysis of which using difference spectra have revealed the interaction of all components of the system. The binding of a copolymer of maleic anhydride with poly(vinylpyridines) has been established, the maximum of which is observed at the ratio copolymer: poly(2-vinylpyridine) = 1 : 1 and copolymer : poly(4-vinylpyridine) = 2 : 1. The structure of complexes between polymers was studied by the PM3; the formation of cooperative hydrogen bonds is shown.
About the Authors
N. O. Shevchuk
Институт физико-органической химии и углехимии им. Л. М. Литвиненко
Россия
Россия
T. G. Tyurina
Институт физико-органической химии и углехимии им. Л. М. Литвиненко
Россия
Россия
S. P. Kobzev
Институт физико-органической химии и углехимии им. Л. М. Литвиненко
Россия
Россия
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Review
For citations:
Shevchuk N.O., Tyurina T.G., Kobzev S.P. Studying the interaction of chloramphenicol with maleic anhydride copolymer and polyvinylpyridines. Vestnik of Novgorod State University. 2021;(4(125)):83-86. (In Russ.) https://doi.org/10.34680/2076-8052.2021.4(125).83-86
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