Dynamics of components of metabolic syndrome in children and adolescents with constitutional-exogenous obesity

Abstract

The article presents the results of the study of the components of the metabolic syndrome in children and adolescents with constitutional-exogenous obesity. A comprehensive clinical and instrumental examination of 30 children and adolescents aged 10 to 17 years with constitutional-exogenous obesity of various degrees was initially carried out in a hospital. The data of anamnesis, clinical picture, indicators of fat and carbohydrate metabolism were analyzed. All children and adolescents had a hereditary burden of obesity and associated diseases including arterial hypertension, type II diabetes mellitus. The components of the metabolic syndrome (abdominal obesity, hypertension, insulin resistance, impaired carbohydrate tolerance, hyperuricemia) have been identified in the examined patients. Abdominal obesity has been observed in 36.6% of children; arterial hypertension occurred in 60.0%. Dyslipidemia in the form of hypertriglyceridemia, hypercholesterolemia, a decrease in high-density lipoprotein cholesterol has been observed in 6.6%, 13.3%, 10.0% of patients respectively. In 16.6% of the children, impaired tolerance to carbohydrates was noted, insulin resistance — in 56.6%. After 12 months, control was carried out according to the above parameters in the study group. The statistical calculations carried out did not show significant differences between the initial data and after 12 months. The results obtained indicate that cardiometabolic risks in these patients persist and may have unfavorable prognostic outcomes.