Disturbances of innate immunity in gestational acute pyelonephtis
https://doi.org/10.34680/2076-8052.2025.4(142).667-682
Abstract
The purpose of this study is to identify violations of the parameters of innate immunity in acute serous pyelonephritis depending on the trimester of gestation. The study included 110 women divided into groups. The main study groups (15 women in each) consisted of pregnant patients in the first, second and third trimesters with a verified diagnosis of "Acute gestational serous pyelonephritis". In the circulating peripheral blood, the parameters of innate immunity were studied: functional and metabolic activity of neutrophils, cytokine spectrum, the state of the complement system. In patients with acute pyelonephritis in the 1st-3rd trimesters of gestation, compared with the group of pregnant patients without renal pathology, suppression of the activity and phagocytic intensity, an increase in the oxygen-dependent activity of circulating blood neutrophils, an increase in the content of C5, C5a complement components in blood plasma, a decrease in the content of the C3a component and inhibitors of the complement system (factor H and C1-ing.), an increase in the cytokines TNFα, IL-1β, IL-6, IL-8, IL-17, IFNγ, IL-4 and IL-10 were revealed, which can be considered as immune inflammation at the systemic level, more pronounced in the 2nd and 3rd trimesters of pregnancy. The basic treatment of acute pyelonephritis does not normalize most of the studied altered parameters of innate immunity in these trimesters. The results of the studies complement the existing data on the immunopathogenesis of the development of acute pyelonephritis in each trimester of gestation and are the basis for revising the treatment protocols for acute pyelonephritis in pregnant women.
About the Authors
I. M. Kholimenko
Kursk regional multidisciplinary clinical hospital
Россия
Россия
Kursk
A. A. Konoplya
Limited Liability Company "STOMED"
Россия
Россия
Moscow
N. M. Kholimenko
Kursk regional multidisciplinary clinical hospital
Россия
Россия
Kursk
M. N. Shatokhin
Russian Medical Academy of Continuous Professional Education
Россия
Россия
Moscow
A. Yu. Kravtsov
Limited Liability Company "STOMED"
Россия
Россия
Moscow
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Review
For citations:
Kholimenko I.M., Konoplya A.A., Kholimenko N.M., Shatokhin M.N., Kravtsov A.Yu. Disturbances of innate immunity in gestational acute pyelonephtis. Vestnik of Novgorod State University. 2025;(4(142)):667-682. (In Russ.) https://doi.org/10.34680/2076-8052.2025.4(142).667-682
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