Giant cell hepatitis: pathomorphology and diagnostic challenges
https://doi.org/10.34680/2076-8052.2025.4(142).554-565
Abstract
In this paper we present an analysis of current literature on neonatal hepatitis, with a particular focus on giant cell hepatitis, and examines epidemiological data on these diseases, including statistics from the Russian Federation. A clinical case of liver involvement in an infant is presented, describing the course of the disease and the pathomorphological features of organ tissues, including the liver. Based on the obtained data, the diagnostic challenges of giant cell hepatitis are substantiated; in this case, they were associated with the rapidly deteriorating condition of the child, as well as the significant contribution of a competing disease to the development of an unfavorable outcome. The presented histological images demonstrate liver damage resulting from an unspecified intrauterine infection. It is important to note that studying this pathology helps ensure timely medical care, improve preventive measures, and increase the likelihood of favorable outcomes in early childhood liver diseases.
About the Authors
V. E. Ermilov
Yaroslav-the-Wise Novgorod State University
Россия
Россия
Veliky Novgorod
A. B. Ershevskaya
Yaroslav-the-Wise Novgorod State University
Россия
Россия
Veliky Novgorod
Ye. Ye. Rumyantsev
Yaroslav-the-Wise Novgorod State University
Россия
Россия
Veliky Novgorod
S. D. Matyushkina
Yaroslav-the-Wise Novgorod State University
Россия
Россия
Veliky Novgorod
References
1. Ermolaeva Y. A., Samarina S. V., Sagan E. V., Zgerskaya T. V., Samoylova Y.G. Congenital Infections: Textbook. Tomsk: SibGMU Publ., 2024. 195 р. (In Russian).
2. Efremova N. A., Goryacheva L. G., Rogozina N. V., Alekseeva L. A., Kotiv M. Ya. Clinical and laboratory features of neonatal hepatitis of various etiologies // Children infections. 2012. 11 (2). 8–11. (In Russian).
3. Ushakova R. A., Kovtun O. P., Beykin Ya. B. Modern aspects of diagnosis, treatment, and prognosis of hepatitis in early childhood: monograph. Yekaterinburg: UGMU Publishing, 2018. 220 р. (In Russian).
4. Khaertynov Kh. S., Anokhin V. A., Nizamova E. R. Clinical and epidemiological features of neonatal hepatitis // Kazan medical journal. 2012. 93 (6). 921–926. (In Russian).
5. Xiao Y., Gao ZH., Deschenes M. Autoimmune post-infantile giant cell hepatitis: a case report and review of the literature // Canadian liver journal. 2021. 4 (2). 104–109. DOI: 10.3138/canlivj-2020-0024
6. Jiao J., Zhang X. Post-infantile Giant Cell Hepatitis: A Literature Review and Meta-analysis // Journal of clinical and translational pathology. 2022. 2 (3). 100–107. DOI: 10.14218/jctp.2022.00016
7. Poddighe D., Madiyeva A., Talipova D., Umirbekova B. Infantile giant cell hepatitis with autoimmune hemolytic anemia // World journal of hepatology. 2021. 13 (4). 411–420. DOI: 10.4254/wjh.v13.i4.411
8. Nastasio S., Matarazzo L., Sciveres M., Maggiore G. Giant cell hepatitis associated with autoimmune hemolytic anemia: an update // Translational gastroenterology and hepatology. 2021. 6. 25. DOI: 10.21037/tgh.2020.03.10
9. Nadeev A. P., Karpov M. A., Abyshev A. A., Ovsyanko E. V. Pathomorphological and etiological characteristics of infectious liver and gastrointestinal tract lesions in newborns // Experimental and clinical gastroenterology. 2020. 182 (10). 65–70. DOI: 10.21037/tgh.2020.03.10 (In Russian).
10. Torbenson M., Hart J., Westerhoff M., Azzam R. K., Elgendi A., Mziray-Andrew H. C., Kim G. E., Scheimann A. Neonatal giant cell hepatitis: histological and etiological findings // The American journal of surgical pathology. 2010. 34 (10). 1498–1503. DOI: 10.1097/PAS.0b013e3181f069ab
11. Kirilochev O. K. Causes, incidence, and possibilities to eliminate diagnostic errors in newborns and infants under one year // Russian bulletin of perinatology and pediatrics. 2020. 65(3). 53–60. DOI: 10.21508/1027-4065-2020-65-3-53-60 (In Russian).
12. Grigoriev K. I., Vykhristyuk O. F. Autoimmune hepatitis in children // The journal of general medicine. 2022. 3–4. 4–13. DOI: 10.24412/2071-5315-2022-12913 (In Russian).
13. Rumyantsev Yе. Yе., Strikanov I. A. The role of morphological examination and laboratory methods in the diagnosis of autoimmune hepatitis // Vestnik NovSU. 2023. 4 (133). 587–598. DOI: 10.34680/2076-8052.2023.4(133).587-598 (In Russian).
14. Csernus K., Tészás A., Ottóffy G., Dezsőfi-Gottl A., Tárnok A. Association of giant cell hepatitis and autoimmune hemolytic anemia in infancy // Orvosi Hetilap. 2023. 164 (36). 1432–1436. DOI: 10.1556/650.2023.32848 (In Hungarian).
Review
For citations:
Ermilov V.E., Ershevskaya A.B., Rumyantsev Ye.Ye., Matyushkina S.D. Giant cell hepatitis: pathomorphology and diagnostic challenges. Vestnik of Novgorod State University. 2025;(4(142)):554-565. (In Russ.) https://doi.org/10.34680/2076-8052.2025.4(142).554-565
Views:
7
JATS XML
Email this article 