Morphofunctional characteristics of bile ducts and their changes in cholestasis
https://doi.org/10.34680/2076-8052.2025.4(142).534-544
Abstract
The morphological structure of the bile ducts was studied in 78 cadavers of people of different ages and sexes, including the topography of organs, vascular-nerve bundles and cellular spaces of the hepatobiliary zone, and body composition features. Age characteristics, anatomical structure and histology of the bile ducts in normal conditions and in benign cholestasis were studied. Clinical data of 130 patients with cholestasis, treated in specialized departments of Veliky Novgorod, were analyzed. A large number of variations in the anatomical structure and location of the bile ducts have been identified. A dependence of duct topography on the shape of the duodenum and the patient's age has been observed, which may be of great importance in diagnosis and surgical interventions. Histological analysis revealed a correlation between the severity of destructive lesions and fibrous tissue proliferation and the duration of cholestasis. Active proliferation of the bile ducts occurs at 7–10 days, followed by their destruction and cirrhosis. The identified duct morphology features should be considered when choosing treatment strategies for cholestasis.
About the Authors
M. D. Kashaeva
Yaroslav-the-Wise Novgorod State University
Россия
Россия
Veliky Novgorod
D. S. Dyukov
Yaroslav-the-Wise Novgorod State University
Россия
Россия
Veliky Novgorod
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Review
For citations:
Kashaeva M.D., Dyukov D.S. Morphofunctional characteristics of bile ducts and their changes in cholestasis. Vestnik of Novgorod State University. 2025;(4(142)):534-544. (In Russ.) https://doi.org/10.34680/2076-8052.2025.4(142).534-544
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