Determination of the state of enzymes in experiment with toxic liver damages

Abstract

In connection with the intensification of anthropogenic pollution of the environment, the problem of diseases of chemical etiology has acquired particular importance. In acute poisoning with different concentrations of toxic substances, it is liver damage (liver failure) in more than 50% of cases that is one of the frequent complications of many pathological conditions, which aggravates the severity of intoxication in general. Clinical manifestations of chronic toxic liver damage are found only in 30% of patients, which can cause acute lesions of the hepatobiliary system and contribute to the development of chronic diseases. Of particular importance is the problem of possible chronicity of the pathological process in individuals employed in chemical production (occupational diseases) and the appearance of combined liver lesions in them. Against the background of combined liver lesions (for example, ethyl alcohol and CCl₄, chloroform, ethylene glycol), a previously hidden, genetically determined defect in the biotransformation function of the liver may be revealed. The severity of toxic liver damage depends primarily on the type of toxic substance (its chemical structure), the dose and duration of its administration, as well as the method of introducing the toxin into the body. These facts determine the relevance and significance of the present study.