Nanoporous membranes based on aluminum oxide for homogenization of a liposomal solution
https://doi.org/10.34680/2076-8052.2023.1(130).9-21
Abstract
The production of liposomal preparations involves the production and reduction of liposomes to sizes ranging from 50 to 200 nm. For these purposes, either the method of sonicating the liposomal solution or its extrusion is used. When using the sonication method, particles with a size of about 200 nm are obtained. At the same time, the extrusion method makes it possible to obtain particles of any size within a given range. The size of the homogenized liposomes is determined by the geometric characteristics of the membrane through which the liposomes pass. The article considers a method for obtaining membranes based on porous anodized alumina and the possibility of using them for homogenization of liposomes. The membranes obtained during the work were anodized in an oxalic acid-based electrolyte in a potentiostatic mode at low temperatures. The layers of barrier aluminum oxide and pure aluminum, covering the reverse side of the pores, were removed by chemical etching in a solution of phosphoric acid and a saturated solution of copper chloride, respectively. As a result, aluminum oxide membranes with a pore diameter of ~100 nm and a thickness of ~100 µm were obtained. The experimental data on the thickness parameters were confirmed by theoretical calculations.
About the Authors
I. E. Anufriev
Saint Petersburg Electrotechnical University "LETI"
Russian Federation
Russian Federation
Anufriev I. E.,
Saint Petersburg.
E. N. Muratova
Saint Petersburg Electrotechnical University "LETI"
Russian Federation
Russian Federation
Muratova E. N.,
Saint Petersburg.
R. G. Valeev
Udmurt Federal Research Center of the Ural Branch of the RAS
Russian Federation
Russian Federation
Valeev R.G.,
Izhevsk.
D. V. Korolev
Almazov National Medical Research Centre of the Ministry of Health of the RF
Russian Federation
Russian Federation
Korolev D.V.,
Saint Petersburg.
V. M. Kondratiev
Alferov Saint Petersburg National Research Academic University of the RAS
Russian Federation
Russian Federation
Kondratiev V.M.,
Saint Petersburg.
V. A. Moshnikov
Saint Petersburg Electrotechnical University "LETI"
Russian Federation
Russian Federation
Moshnikov V.A.,
Saint Petersburg.
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Review
For citations:
Anufriev I.E., Muratova E.N., Valeev R.G., Korolev D.V., Kondratiev V.M., Moshnikov V.A. Nanoporous membranes based on aluminum oxide for homogenization of a liposomal solution. Title in english. 2023;(1(130)):9-21. (In Russ.) https://doi.org/10.34680/2076-8052.2023.1(130).9-21
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