Physiological significance of the family of vascular endothelial growth factors and its role in ophthalmology
https://doi.org/10.34680/2076-8052.2023.2(131).282-291
Abstract
This literature review presents current data on the role of the vascular endothelial growth factor (VEGF) in physiology and pathology and its application in ophthalmology. The main physiological properties of the VEGF family factors and the role of their receptors in the development and regulation of angiogenesis are described. Clarification of the mechanisms of vascular growth in physiological conditions is necessary to understand the processes of formation of new vessels, since their violation underlies the development of many diseases, including in ophthalmology. Medicines used in ophthalmology that inhibit VEGF-mediated angiogenesis are presented in this review. A number of reports describe signs of retinal damage during anti-VEGF therapy. It is currently unclear whether retinal toxicity from VEGF-A neutralization arises from impaired direct VEGF-A-mediated cytoprotection or from an indirect effect such as impaired VEGF-A-mediated vascular perfusion. Therefore, the further study of the physiological role of the vascular endothelial growth factor will allow the development of new medicines for the treatment and prevention of eye diseases.
About the Authors
T. I. Okonenko
Yaroslav-the-Wise Novgorod State University
Russian Federation
Russian Federation
Okonenko T. I.,
Veliky Novgorod.
A. P. Novikova
Yaroslav-the-Wise Novgorod State University
Russian Federation
Russian Federation
Novikova A. P.,
Veliky Novgorod.
G. A. Antropova
Yaroslav-the-Wise Novgorod State University
Russian Federation
Russian Federation
Antropova G. A.,
Veliky Novgorod.
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Review
For citations:
Okonenko T.I., Novikova A.P., Antropova G.A. Physiological significance of the family of vascular endothelial growth factors and its role in ophthalmology. Title in english. 2023;(2(131)):282-291. (In Russ.) https://doi.org/10.34680/2076-8052.2023.2(131).282-291
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