Application of the method of multislice spiral computed tomography to assess the state of lungs in animals with simulated anthracosis

Abstract

Occupational diseases and harmful production factors contribute to a significant disability of the working population. This article discusses some morphological aspects of changes in the lungs of experimental animals after the introduction of coal suspension into the respiratory tract. Specific and non-specific responses of lung tissue to the damage were determined. The object of the study was white outbred rats, formed according to the principle of pairs of analogues, with the separation of the experimental and control groups. On the 10th day of the experiment, the animals were withdrawn from the experiment, with a preliminary multislice computed tomography and subsequent microscopic assessment of the organization of the lung parenchyma. As a result, computed tomography revealed a pronounced reaction with the formation of emphysema in the subpleural parts of the lungs. Microscopic examination revealed non-specific types of responses to the introduction of coal dust with the formation of leukocyte infiltration in various parts of the lungs, accumulation of mucus and coal dust in the respiratory bronchioles.