Effect of cardiovascular comorbidity and concomitant diabetes mellitus on blood biomarkers in patients with COVID-19
https://doi.org/10.34680/2076-8052.2023.2(131).259-267
Abstract
The severity of the condition in patients with the main diagnosis "new coronavirus infection caused by COVID-19 virus, complicated by the development of community-acquired bilateral multisegmental viral pneumonia of moderate severity" was assessed by laboratory parameters in the blood serum (glucose, creactive protein, total protein, cholesterol, creatinine). Patients diagnosed with comorbidities, such as type 2 diabetes mellitus and cardiovascular diseases, in addition to COVID-19, and the control group of patients without comorbidity were included in the study. The presence of diagnosed obesity in the patients was also assessed. Changes in blood serum parameters from the moment of admission and at the time of discharge of the patients, depending on the concomitant pathology, were measured. The most pronounced changes in blood biomarkers were observed in the patients with a combination of concomitant cardiovascular diseases and concomitant diabetes mellitus. When comparing the two groups, with only cardiovascular comorbidity and only concomitant diabetes mellitus, a greater effect of concomitant cardiovascular diseases on blood biomarkers in the patients was noted. Separately it is worth noting obesity as a factor affecting the pathological increase in blood glucose levels in the patients after even a short-term COVID-19 treatment.
About the Authors
Ye. Ye. RumyantsevRussian Federation
Rumyantsev Ye. Ye.,
Veliky Novgorod.
K. Yu. Kartysheva
Russian Federation
Kartysheva K. Yu.,
Veliky Novgorod.
S. V. Merbakh
Russian Federation
Merbakh S. V.,
Veliky Novgorod.
A. K. Iskandaryan
Russian Federation
Iskandaryan A. K.,
Veliky Novgorod.
References
1. Shestakova M. V., Vikulova O. K., Isakov M. A., Dedov I. I. Saharnyj diabet i COVID-19: analiz klinicheskih iskhodov po dannym registra saharnogo diabeta Rossijskoj Federacii [Diabetes mellitus and COVID-19: analysis of clinical outcomes according to the data of the register of diabetes mellitus of the Russian Federation] // Problems of Endocrinology. 2020. 66(1). 35-46. DOI: 10.14341/probl12458
2. Bondarenko A. L., Averina V. M., Grishin A. P., Tihanushkina A. A. COVID-19 u bol'nyh saharnym diabetom II tipa [COVID-19 in patients with type II diabetes mellitus] // Medical Newsletter of Vyatka. 2022. 3(75). 4-8. DOI: 10.24412/2220-7880-2022-3-4-8
3. Gurevich M. A. Saharnyj diabet i zabolevaniya serdechno-sosudistoj sistemy [Diabetes mellitus and diseases of the cardiovascular system] // Russian Medical Journal. 2017. 25(20). 1490-1494.
4. Pogorova M. R., Beremukova M. A., Shavaeva K. A., Zhidkov R. S. Techenie COVID-19 u pacientov s saharnym diabetom [The course of COVID-19 in patients with diabetes mellitus] // Questions of science and education. 2022. 1(157). 22–25.
5. Shestakova M. V., Shestakova E. A., Sklyanik I. A., Stafeev Yu. S. Ozhirenie i saharnyj diabet – vsegda li vmeste? [Are obesity and diabetes always together?] // Therapeutic archive. 2022. 94(10). 1131–1135. DOI: 10.26442/00403660.2022.10.201880
6. Townsend N., Kazakiewicz D., Wright F.L., Timmis A., Huculeci R., Torbica A., Gale C.P., Achenbach S., Weidinger F., Vardas P. Epidemiology of cardiovascular disease in Europe // Nature Reviews Cardiology. 2022. 19(2). 133-143. DOI: 10.1038/s41569-021-00607-3
7. Pepera G., Tribali M.-S., Batalik L., Petrov I., Papathanasiou J. Epidemiology, risk factors and prognosis of cardiovascular disease in the Coronavirus Disease 2019 (COVID-19) pandemic era: A systematic review // Reviews in Cardiovascular Medicine. 2022. 23(1). 28. DOI: 10.31083/j.rcm2301028
8. Zanza C., Romenskaya T., Chiara Manetti A., Franceschi F., La Russa R., Bertozzi G., Maiese A., Savioli G., Volonnino G., Longhitano Y. Cytokine storm in COVID-19: immunopathogenesis and therapy // Medicina (Kaunas). 2022. 58(2). 144. DOI: 10.3390/medicina58020144
9. Tolochko M. V., Leiderman I. N., Khokhunov O. A., Mazurok V. A., Rzheutsky R. E. Analiz klinicheskoj effektivnosti deksametazona u pacientov so srednetyazhelym techeniem COVID-19 [Analysis of the clinical efficacy of dexamethasone in patients with moderate COVID-19] // General Reanimatology. 2022. 18(1). 11–16. DOI: 10.15360/1813-9779-2022-1-11-16
10. Antsiferov M. B., Belevsky A. S., Bulanov A. Y., Vasilyev E. Y., Zhuravlev M. V., Zagrebnev A. I., Zairatyants O. V., Lysenko M. A., Mazus A. I., Morozov S. P., Petrikov S. S., Plavunov N. F., Popugaev K. A., Protsenko D. N., Smetanina S. V., Tokarev A. S., Tyazhelnikov A. A., Vinodaeva Yu. V., Fomina D. S., Tsyganova E. V., Tsibin A. N., Churadze B. T. Klinicheskij protokol lecheniya bol'nyh novoj koronavirusnoj infekciej COVID-19, nahodyashchihsya na stacionarnom lechenii v medicinskih organizaciyah gosudarstvennoj sistemy zdravoohraneniya goroda Moskvy [Clinical protocol for the treatment of patients with a new coronavirus infection COVID-19 who are on inpatient treatment in medical organizations of the state healthcare system of the city of Moscow]. Ed. A.I. Khripun. Moscow, Research Institute NIIOZMM Publ., 2020. 28 p.
11. Djerieva I. S., Volkova N. I., Davydenko I. Y., Reshetnikov I. B., Brovkina S. S., Avakova S. M., Tishchenko Yu. V. Glyukokortikoidnaya terapiya – faktor riska serdechnososudistyh zabolevanij [Glucocorticoid therapy – a risk factor for cardiovascular diseases] // Medical Herald of the South of Russia. 2022. 13(3). 93-106. DOI: 10.21886/2219-8075-2022-13-3-93-106
12. Vaishnavi K. Vpervye vyyavlennaya giperglikemii pri terapii pnevmonii COVID-19 [For the first time revealed hyperglycemia in the treatment of pneumonia COVID-19] // Youth, science, medicine: abstracts of the 68th All-Russian Interuniversity Student Scientific Conference with international participation, April 20–21, 2022. Tver, Tver State Medical Academy, 2022. P. 64-65.
13. Urunova F. Z., Shakhidabonu A. A., Bazarova V. R., Bakhronova M. B., Daminov A. T. Oslozhneniya glyukokortikoidnoj terapii pri COVID-19 na fone saharnogo diabeta 2-tipa [Complications of glucocorticoid therapy in COVID-19 on the background of type 2 diabetes mellitus] // Science and Education. 2023. 4(2). 520-529.
14. Biliktueva K. D. Issledovanie narushenij uglevodnogo obmena u pacientov s COVID-19 po materialam infekcionnyh monostacionarov g. Chity [Investigation of carbohydrate metabolism disorders in patients with COVID-19 based on the materials of infectious monostationaries of Chita] // Medicine of tomorrow: materials of the XXI interregional scientific and practical conference of students and young scientists with international participation, April 19–22, 2022, Chita. Ed. D.M. Serkin. Chita, Chita State Medical Academy, 2022. Р. 30-31.
15. Petrov V. I., Shatalova O. V., Glazova G. M. Mekhanizmy razvitiya giperglikemii i sposoby eyo korrekcii pri novoj koronavirusnoj infekcii [Mechanisms of hyperglycemia development and ways of its correction in a new coronavirus infection] // The Siberian Journal of Clinical and Experimental Medicine. 2022. 37(4). 22-30. DOI: 10.29001/2073-8552-2022-37-4-22-30
16. Han E., Fritzer-Szekeres M., Szekeres T., Gehrig T., Gyöngyösi M., Bergler-Klein J. Comparison of High-Sensitivity C-Reactive Protein vs C-reactive Protein for Cardiovascular Risk Prediction in Chronic Cardiac Disease // The Journal of Applied Laboratory Medicine. 2022. 7(6). 1259-1271. DOI: 10.1093/jalm/jfac069
17. Tang Y., Hu L., Liu Y., Zhou B., Qin X., Ye J., Shen M., Wu Z., Zhang P. Possible mechanisms of cholesterol elevation aggravating COVID-19 // International journal of medical sciences. 2021. 18(15). 3533-3543. DOI: 10.7150/ijms.62021
Review
For citations:
Rumyantsev Ye.Ye., Kartysheva K.Yu., Merbakh S.V., Iskandaryan A.K. Effect of cardiovascular comorbidity and concomitant diabetes mellitus on blood biomarkers in patients with COVID-19. Title in english. 2023;(2(131)):259-267. (In Russ.) https://doi.org/10.34680/2076-8052.2023.2(131).259-267