Chronobiological mechanisms in the pathophysiology of pediatric type 1 diabetes mellitus
https://doi.org/10.34680/2076-8052.2023.2(131).234-241
Abstract
A total of 70 children were studied, including 35 with type 1 diabetes mellitus (study group) and 35 conditionally healthy children (control group). Patients with type 1 diabetes mellitus were studied at two stages: upon their urgent admission to the hospital with diabetic ketoacidosis (stage one, acute period) and two months later, during planned hospitalization (stage two, recovery period). Children with type 1 diabetes mellitus were found to have elevated levels of autoantibodies against the melatonin receptor (MRA1), with the maximum concentration during the acute period reaching 5.17±1.02 U/mL and subsequent gradual decrease to a level of 2.3±0.31 U/mL two months later. Positive correlation was found between the level of anti-MRA1 AAT and chronic disease course (duration of disease, number of relapses in the patient’s history). An explanation is provided for chronobiological mechanisms involved in the pathophysiology of pediatric type 1 diabetes mellitus.
About the Authors
Yu. V. Bykov
Stavropol State Medical University of Ministry of Health of Russian Federation
Russian Federation
Russian Federation
Bykov Yu. V.,
Stavropol.
V. A. Baturin
Stavropol State Medical University of Ministry of Health of Russian Federation
Russian Federation
Russian Federation
Baturin V. A.,
Stavropol.
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For citations:
Bykov Yu.V., Baturin V.A. Chronobiological mechanisms in the pathophysiology of pediatric type 1 diabetes mellitus. Title in english. 2023;(2(131)):234-241. (In Russ.) https://doi.org/10.34680/2076-8052.2023.2(131).234-241
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