Densitometric assessment of various anatomical structures of white laboratory mice by high-resolution computed tomography

Abstract

The technical aspects of conducting a high-resolution multispiral study are considered. The study was performed on adult  outbred ICR mice (CD-1) of the same age, sex, and body weight. A total of 10 males aged 7 months have been studied. For the first time in the domestic scientific literature, a descriptive analysis of the results of spiral computer tomography (SCT) examination of laboratory mice is given and the density characteristics of their tissues are described. The main features of X-ray anatomy of the chest and abdominal organs are indicated. The values of X-ray density of the brain, lungs, liver, bone tissue are shown. The possibility of using various post-processing programs for in-depth analysis is considered. The absence of a significant difference in the density of bone tissue and lungs of the left and right parts of the body has been noted, the density of various parts of the bones has been assessed, differences in density between different bones and different parts of the same bones of the limbs are shown. The results obtained can be used in further assessment of age-related changes.