Serine proteases in the functional activity of the nervous system
https://doi.org/10.34680/2076-8052.2023.2(131).196-207
Abstract
Serine proteases, including trypsin, thrombin, plasminogen activators, plasmin and several others, are synthesized in nervous tissue, mainly in the brain, including the cortex, limbic system and cerebellum. This review examines the involvement of serine proteases in neuroplasticity and behavioral regulation. Endogenous serine proteases play an important role in the formation, development and maintenance of the nervous system. Through limited proteolysis, these proteases activate PARs (protease-activated receptors), modify other receptors or their ligands, process neurotrophic factors, degrade intercellular matrix and cell adhesion proteins and initiate complex signal transduction cascades necessary for structural modification of synapses. The involvement of serine proteases in morphological and functional synaptic plasticity may underlie cognitive processes, including learning and memory in animals and humans.
About the Authors
T. S. Zamolodchikova
Research Institute of Normal Physiology named after P. K. Anokhin
Russian Federation
Russian Federation
Zamolodchikova T. S.,
Moscow.
S. M. Tolpygo
Research Institute of Normal Physiology named after P. K. Anokhin
Russian Federation
Russian Federation
Tolpygo S. M.,
Moscow.
A. V. Kotov
Yaroslav-the-Wise Novgorod State University
Russian Federation
Russian Federation
Kotov A. V.,
Veliky Novgorod.
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Review
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Zamolodchikova T.S., Tolpygo S.M., Kotov A.V. Serine proteases in the functional activity of the nervous system. Title in english. 2023;(2(131)):196-207. (In Russ.) https://doi.org/10.34680/2076-8052.2023.2(131).196-207
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