vestnovsuВестник Новгородского государственного университетаVestnik of Novgorod State University2076-8052Новгородский государственный университет имени Ярослава Мудрого10.34680/2076-8052.2025.2(140).273-290vestnovsu-383Research ArticleПАТОЛОГИЧЕСКАЯ ФИЗИОЛОГИЯPATHOPHYSIOLOGYРоль микроРНК в регуляции окислительного стресса при эндометриозеThe role of MicroRNAs in the regulation of oxidative stress in endometriosishttps://orcid.org/0000-0001-6487-9083ОсиковМ. В.OsikovM. V.

Осиков Михаил Владимирович – доктор медицинских наук, профессор, заведующий кафедрой, ЮУГМУ; руководитель отдела, Челябинская ОКБ.

Челябинск

Chelyabinsk

prof.osikov@yandex.ruhttps://orcid.org/0000-0003-2309-2983КурносенкоИ. В.KurnosenkoI. V.

Курносенко Илона Владимировна – доктор медицинских наук, доцент, заведующий кафедрой, ЮУГМУ; гинеколог, Областной перинатальный центр.

Челябинск

Chelyabinsk

kurnosenko.ilona@gmail.comhttps://orcid.org/0009-0006-5127-7618КрюковВ. А.KryukovV. A.

Крюков Владимир Александрович – ассистент, ЮУГМУ; врач-гинеколог, Челябинская ОКБ.

Челябинск

Chelyabinsk

vovchik-92@bk.ruЮжно-Уральский государственный медицинский университет; Челябинская областная клиническая больницаРоссияSouth-Ural state medical university; Chelyabinsk regional clinical hospitalRussian FederationЮжно-Уральский государственный медицинский университет; Областной перинатальный центрРоссияSouth-Ural state medical university; Regional perinatal centerRussian Federation20251808202502(140)273290Copyright © Осиков М.В., Курносенко И.В., Крюков В.А., 20252025Осиков М.В., Курносенко И.В., Крюков В.А.Osikov M.V., Kurnosenko I.V., Kryukov V.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestnovsu.elpub.ru/jour/article/view/383

Микрорибонуклеиновые кислоты (микроРНК) – короткие одноцепочечные некодирующие рибонуклеиновые кислоты. МикроРНК участвуют в регуляции многих процессов, участвующих в поддержании гомеостаза в норме, а также в патогенезе многих заболеваний, в частности, их роль подтверждена в формировании окислительного стресса. В основе окислительного стресса лежит гиперпродукция активных форм кислорода и/или дефицит антиоксидантов. В настоящее время окислительный стресс рассматривается как одно из ключевых звеньев патогенеза эндометриоза. Была доказана роль ряда микроРНК (miR-21, miR-23a, miR-30a, miR-34a, miR-125b, miR-132, miR-146a, miR-155, miR-200c, miR-205, miR-484, miR-6516-5p) в регуляции окислительного стресса за счет прямого и опосредованного действия на транскрипцию антиоксидантных ферментов. В связи с участием в регуляции редокс-статуса при эндометриозе микроРНК могут выступать в роли потенциальных диагностических и прогностических маркеров эндометриоза, включая оценку тяжести и прогрессирование по стадиям.

Micro ribonucleic acids (microRNA) are short, single-stranded non-coding RNA molecules that play a critical role in regulating a wide range of biological processes essential for maintaining homeostasis under physiological conditions. In addition to their functions in normal cellular regulation, miRNAs are increasingly recognized for their involvement in the pathogenesis of various diseases, particularly through their influence on oxidative stress mechanisms. Oxidative stress results from an imbalance between the excessive production of reactive oxygen species and a deficiency in antioxidant defenses. It is now acknowledged as a key contributor to the development and progression of endometriosis. Recent studies have identified several microRNAs (miR-21, miR-23a, miR-30a, miR-34a, miR-125b, miR-132, miR-146a, miR-155, miR-200c, miR-205, miR-484, and miR-6516-5p) that regulate oxidative stress by directly or indirectly modulating the transcription of antioxidant enzymes. Given their role in modulating redox status in endometriosis, these microRNAs may serve as valuable diagnostic and prognostic markers for the condition, aiding in the assessment of severity and stage progression.

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The authors declare that there are no conflicts of interest present.