vestnovsuВестник Новгородского государственного университетаVestnik of Novgorod State University2076-8052Новгородский государственный университет имени Ярослава Мудрого10.34680/2076-8052.2021.3(124).82-89vestnovsu-204Research ArticleФармакология, клиническая фармакологияPharmacology, clinical pharmacologyМорфологическая и биохимическая оценка противофиброзной активности экстрактов плодов семейства вересковые, произрастающих на территории ЮгрыMorphological and biochemical evaluation of the antifibrotic activity of the heather family berries extracts growing in Yugra regionКривыхЕ. А.KrivykhE. A.

Ханты-Мансийск

krivyhEA@hmgma.ruКавушевскаяН. С.KavushevskayaN. S.

Сургут

natalya.kavushevskaya@mail.ruГуляевА. Е.GuliaevA. Е.

Нур-Султан

КоваленкоЛ. В.KovalenkoL. V.

Сургут

Ханты-Мансийская государственная медицинская академияRussian FederationСургутский государственный университетRussian FederationNational Laboratory AstanaKazakhstan20212409202303(124)8289Copyright © Кривых Е.А., Кавушевская Н.С., Гуляев А.Е., Коваленко Л.В., 20232023Кривых Е.А., Кавушевская Н.С., Гуляев А.Е., Коваленко Л.В.Krivykh E.A., Kavushevskaya N.S., Guliaev A.Е., Kovalenko L.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestnovsu.elpub.ru/jour/article/view/204

Работа посвящена определению гепатопротекторных свойств полифенольных экстрактов плодов клюквы обыкновенной (Vaccinium oxycoccus L.), черники обыкновенной (Vaccinium myrtillus L.), брусники обыкновенной (Vaccinium vitis-idaea L.) и голубики обыкновенной (Vaccinium uliginosum L.). Исследование проведено на 70 крысах-самцах линии Wistar 7-8 месяцев, массой тела 210-230 г. Фиброз печени был моделирован путем токсического поражения раствором четыреххлористого углерода (CCl4) — 0,2 мл/100 г массы тела в рафинированном оливковом масле (1:1). Доказано, что полифенольные экстракты плодов черники обыкновенной (Vaccinium myrtillus L.) (наиболее выражено), голубики обыкновенной (Vaccinium uliginosum L.), клюквы обыкновенной (Vaccinium oxycoccus L.) и брусники обыкновенной (Vaccinium vitis-idaea L.) (в наименьшей степени) могут уменьшать выраженность повреждений печени, вызываемых CCl4. Полученные сведения позволяют предполагать возможность применения исследуемых экстрактов в качестве корректоров процесса фиброза.

The focus of the paper is to determine hepatoprotective properties of polyphenolic extracts of the fruits of cranberry (Vaccinium oxycoccus L.), blueberry (Vaccinium myrtillus L.), cranberry (Vaccinium vitis-idaea L.) and blueberry (Vaccinium uliginosum L.). The study was conducted on 70 male Wistar rats aged 7-8 months, weighing 210-230 g. Liver fibrosis was modeled by toxic damage with a solution of carbon tetrachloride (CCl4) – 0.2 ml/100g of body weight in refined olive oil (1:1). It has been proven that polyphenolic extracts of blueberry (Vaccinium myrtillus L.) (most pronounced), blueberry (Vaccinium uliginosum L.), cranberry (Vaccinium oxycoccus L.) and cranberry (Vaccinium vitis-idaea L.) (least pronounced) can reduce the severity of liver damage caused by CCl4. The obtained data suggest that the studied extracts can be used as correcting agents for fibrosis.

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The authors declare that there are no conflicts of interest present.