<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vestnovsu</journal-id><journal-title-group><journal-title xml:lang="ru">Вестник Новгородского государственного университета</journal-title><trans-title-group xml:lang="en"><trans-title>Vestnik of Novgorod State University</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2076-8052</issn><publisher><publisher-name>Новгородский государственный университет имени Ярослава Мудрого</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.34680/2076-8052.2021.3(124).58-60</article-id><article-id custom-type="elpub" pub-id-type="custom">vestnovsu-198</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Клиническая иммунология. Аллергология. Инфекционные болезни</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Clinical immunology and infectious diseases. Allergology</subject></subj-group></article-categories><title-group><article-title>COVID-19 и типы аллергических реакций</article-title><trans-title-group xml:lang="en"><trans-title>COVID-19 and types of allergic reactions</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Болотская</surname><given-names>Л. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Bolotskaya</surname><given-names>L. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сургут</p></bio><email xlink:type="simple">pathology528@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Смышляева</surname><given-names>Р. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Smyshlyaeva</surname><given-names>R. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сургут</p></bio><email xlink:type="simple">pathology528@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>Сургутский государственный университет ХМАО-Югры</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>23</day><month>09</month><year>2023</year></pub-date><volume>0</volume><issue>3(124)</issue><fpage>58</fpage><lpage>60</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Болотская Л.А., Смышляева Р.К., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Болотская Л.А., Смышляева Р.К.</copyright-holder><copyright-holder xml:lang="en">Bolotskaya L.A., Smyshlyaeva R.K.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://vestnovsu.elpub.ru/jour/article/view/198">https://vestnovsu.elpub.ru/jour/article/view/198</self-uri><abstract><p>Нами проанализирована взаимосвязь этапов формирования и развития реакций III типа и коронавирусной инфекции и общность патогенеза. Этиологический фактор, связанный с вирусом SARS-CoV-2, генетические факторы, медиаторы воспаления, тканевое повреждение, фармакотерапия демонстрируют много сходного с данным типом аллергических реакций</p></abstract><trans-abstract xml:lang="en"><p>We have analyzed the relationship between the stages of formation and development of type III reactions and coronavirus infection and the generality of pathogenesis. The etiological factor associated with the SARS-CoV-2 virus, genetic factors, inflammatory mediators, tissue damage, pharmacotherapy have much in common with this type of allergic reaction.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>типы иммунных реакций</kwd><kwd>аутоммунные заболевания</kwd><kwd>аутоиммунитет</kwd><kwd>эндотелиальная дисфункция</kwd><kwd>SARS-CoV-2</kwd></kwd-group><kwd-group xml:lang="en"><kwd>types of immune responses</kwd><kwd>autoimmune diseases</kwd><kwd>autoimmunity</kwd><kwd>endothelial dysfunction</kwd><kwd>SARS-CoV-2</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Болотская Л.A. Типы аллергических реакций, механизмы их развития. III тип аллергических реакций. Ч. I. // Вестник СурГУ. Медицина. 2016. №3(29). С.6-14.</mixed-citation><mixed-citation xml:lang="en">Bolotskaia L.A. Tipy allergicheskikh reaktsii, mekhanizmy ikh razvitiia. III tip allergicheskikh reaktsii. Ch. I. // Vestnik SurGU. Meditsina. 2016. №3(29). S.6-14.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Литвицкий П.Ф. Иммунопатологические синдромы. Аллергия. // Вопросы современной педиатрии. 2007 Т.6. №5. С.82-86.</mixed-citation><mixed-citation xml:lang="en">Litvitsky P.F. Immunopathological syndromes. Allergy. // Questions of modern pediatrics. 2007. Vol.6. No. 5. S.82-86.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Ярилин А. А. Иммунология. М.: ГЭОТАРМедиа, 2010. 752 с.</mixed-citation><mixed-citation xml:lang="en">Yarilin A. A. Immunology. M.: GEOTARMedia, 2010. Р.752.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Москалец О.В. Роль инфекции в развитии аутоиммунных заболеваний. // Казанский медицинский журнал. 2017. Т.98. №4. С.586-591.</mixed-citation><mixed-citation xml:lang="en">Moskalets O.V. The role of infection in the development of autoimmune diseases. // Kazan medical journal. 2017. T.98. No. 4. S. 586-591.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Tay M.Z., Poh C.M., Rénia L. et al. The trinity of COVID-19: immunity, inflammation and intervention // Nat. Rev. Immunol. 2020. V.20. P.363-374. DOI: https://doi.org/10.1038/s41577-020-0311-8</mixed-citation><mixed-citation xml:lang="en">Tay M.Z., Poh C.M., Rénia L. et al. The trinity of COVID19: immunity, inflammation and intervention. Nat. Rev. Immunol. 2020. 20: 363–374. DOI:10.1038/s41577-020-0311-8</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Huang K.J., Su I.J., Theron M. et al. An interferon-gammarelated cytokine storm in SARS patients // J. Med. Virol. 2005. V.75(2). P.185-194. DOI: https://doi.org/10.1002/jmv.20255</mixed-citation><mixed-citation xml:lang="en">Huang K.J., Su I.J., Theron M. et al. An interferon-gammarelated cytokine storm in SARS patients. J. Med. Virol. 2005. 75(2): 185–194. DOI:10.1002/jmv.20255</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Nile S.H., Nile A., Qiu J. et al. COVID-19: Pathogenesis, cytokine storm and therapeutic potential of interferons // Cytokine Growth Factor Rev. 2020. V.53. P.66-70. DOI: https://doi.org/10.1016/j.cytogfr.2020.05.002</mixed-citation><mixed-citation xml:lang="en">Nile S.H., Nile A., Qiu J. et al. COVID-19: Pathogenesis, cytokine storm and therapeutic potential of interferons. Cytokine Growth Factor Rev. 2020. S1359–6101(20)30070- 8. DOI:10.1016/j.cytogfr.2020.05.002</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Lite C., Ahmed S.S.S.J., Juliet M ., Freddy A.J. SARSCoV-2/human interactome reveals ACE2 locus crosstalk with the immune regulatory network in the host // Pathogens and disease. 2021. V.79(2). Article number: ftab005. DOI: https://doi.org/10.1093/femspd/ftab005</mixed-citation><mixed-citation xml:lang="en">Lite C., Ahmed S.S.S.J., Juliet M ., Freddy A.J. SARS-CoV2/human interactome reveals ACE2 locus crosstalk with the immune regulatory network in the host. // Pathogens and disease. 2021. 79(2). DOI: 10.1093/femspd/ftab005</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Zareh-Shahamati S., Noorbakhsh M., Digaleh H., SafarpourLima B. Severe acute respiratory syndrome coronavirus 2 and seizure: An insight into the pathophysiologic mechanisms // Current journal of neurology. 2021. V.20. №1. Р.43-48.</mixed-citation><mixed-citation xml:lang="en">Zareh-Shahamati S., Noorbakhsh M., Digaleh H., SafarpourLima B. Severe acute respiratory syndrome coronavirus 2 and seizure: An insight into the pathophysiologic mechanisms. // Current journal of neurology. 2021. 20. №1. Р. 43-48.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Кондратова М.С. Не «просто грипп» или особенности иммунного ответа при COVID-19. // Природа. 2020. №6. С.3-7. DOI: https://doi.org/10.7868/S0032874X20060010</mixed-citation><mixed-citation xml:lang="en">Kondratova M.S. Not “just the flu” or the pattern of the immune response in COVID-19. // Nature. 2020. No. 6. - P.3-7. DOI: 10.7868/S0032874X20060010. Belov B.S., Muravyova N.V., Tarasova G.M. COVID-19 and rheumatology: so far, so close. // Medical advice. 2020. - No. 8. S. 135-143. DOI: 10.21518/2079-701X-2020-8-135-143</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Mehta P., McAuley D.F., Brown M. et al. COVID-19: consider cytokine storm syndromes and immunosuppression. // Lancet. 2020. Vol.395 (10229). P.1033–1034. DOI: https://doi.org/10.1016/S0140-6736(20)30628-0</mixed-citation><mixed-citation xml:lang="en">Mehta P., McAuley D.F., Brown M., Sanchez E., Tattersall R.S, Manson J.J. COVID-19: consider cytokine storm syndromes and immunosuppression. // Lancet. 2020; 395(10229):1033-1034. DOI: 10.1016/S0140-6736(20)30628-0</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Белов Б.С., Муравьева Н.В., Тарасова Г.М. COVID-19 и ревматология: так далеко, так близко // Медицинский совет. 2020. №8. С.135-143. DOI: https://doi.org/10.21518/2079-701X-2020-8-135-143</mixed-citation><mixed-citation xml:lang="en">Belov B.S., Muravyova N.V., Tarasova G.M. COVID-19 and rheumatology: so far, so close. // Medical advice. 2020. No. 8. S. 135-143. DOI: 10.21518/2079-701X-2020-8-135-143</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Насонов Е.Л. Проблемы аутоиммунитета и аутовоспаления в ревматологии: уроки коронавирусной болезни – 2019 (COVID-19). // Педиатрия. Журнал им. Г.Н.Сперанского. 2021. Т.100. №2. С.12-16 DOI: https://doi.org/10.24110/0031-403X-2021-100-2-12-17</mixed-citation><mixed-citation xml:lang="en">Nasonov E.L. Problems of autoimmunity and autoinflammation in rheumatology: lessons from coronavirus disease - 2019 (COVID-19). // Pediatrics. Journal them. G.N. Speransky. 2021. T.100. No. 2. S. 12-16 DOI: 10.24110/0031-403X-2021-100-2-12-17</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Merrill J.T., Erkan D., Winakur J., Judith A. James. Emerging evidence of a COVID-19 thrombotic syndrome has treatment implications // Nat. Rev. Rheumatol. 2020. V.16 (10). P.581- 589. DOI: https://doi.org/10.1038/s41584-020-0474-5</mixed-citation><mixed-citation xml:lang="en">Merrill J.T., Erkan D, Winakur J, Judith A. James. Emerging evidence of a COVID-19 thrombotic syndrome has treatment implications. // Nat. Rev. Rheumatol. 2020; 16 (10): 581– 589. DOI: 10.1038/s41584-020-0474-5.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Стрельникова Е.А., Трушкина П.Ю., Суров И.Ю. и др. Эндотелий in vivo и in vitro. Часть 1: гистогенез, структура, цитофизиология и ключевые маркеры. // Наука молодых. 2019. Т.7. №3. С.450-465. DOI: https://doi.org/10.23888/HMJ201973450-465</mixed-citation><mixed-citation xml:lang="en">Strelnikova E.A., Trushkina P.Yu., Surov I.Yu., Korotkova N.V., Mzhavanadze N.D., Deev R.V. Endothelium in vivo and in vitro. Part 1 Histogenesis, structure, cytophysiology and key markers. // Science of the Young. 2019. T.7. Number 3. S. 450-465. DOI: 10.23888/HMJ201973450-465</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Чамсутдинов Н.У., Абдулманапова Д.Н. Диагностика и лечение COVID-19 и атипичной пневмонии, вызванной SARS-CoV-2 // Вестник ДГМА. 2020. № 2 (35). С.40-61.</mixed-citation><mixed-citation xml:lang="en">Chamsutdinov N. U., Abdulmanapova D. N. Diagnostics and treatment of COVID-19 and atypical pneumonia caused by SARS-CoV-2 / / Vestnik DGMA. 2020. №. 2 (35). Р.40- 61.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
