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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vestnovsu</journal-id><journal-title-group><journal-title xml:lang="ru">Вестник Новгородского государственного университета</journal-title><trans-title-group xml:lang="en"><trans-title>Vestnik of Novgorod State University</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2076-8052</issn><publisher><publisher-name>Новгородский государственный университет имени Ярослава Мудрого</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.34680/2076-8052.2021.3(124).47-50</article-id><article-id custom-type="elpub" pub-id-type="custom">vestnovsu-196</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Патологическая физиология. Клеточная биология, цитология, гистология</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Pathophysiology. Cell biology, cytology, and histology</subject></subj-group></article-categories><title-group><article-title>Патогенетическое значение психологического стресса в развитии нарушений углеводного обмена</article-title><trans-title-group xml:lang="en"><trans-title>Pathogenetic significance of psychological stress in the development of carbohydrate exchange disorders</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Салехова</surname><given-names>М. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Salekhova</surname><given-names>M. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Караганда</p></bio><email xlink:type="simple">salekhova_m@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Максимюк</surname><given-names>Н. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Maksimyuk</surname><given-names>N. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Великий Новгород</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Игимбаева</surname><given-names>Г. Т.</given-names></name><name name-style="western" xml:lang="en"><surname>Igimbaeva</surname><given-names>G. T.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Караганда</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Абдуллоев</surname><given-names>С. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Abdulloev</surname><given-names>S. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Душанбе</p></bio><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Богдашов</surname><given-names>Д. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Bogdashov</surname><given-names>D. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Великий Новгород</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Салехова</surname><given-names>Д. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Salekhova</surname><given-names>D. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Караганда</p></bio><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>«Alanda clinic ltd»</institution><country>Kazakhstan</country></aff><aff xml:lang="ru" id="aff-2"><institution>Новгородский государственный университет имени Ярослава Мудрого</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-3"><institution>Медицинский университет Караганды</institution><country>Kazakhstan</country></aff><aff xml:lang="ru" id="aff-4"><institution>Таджикский государственный медицинский университет имени Абу-али ибни Сино</institution><country>Tajikistan</country></aff><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>23</day><month>09</month><year>2023</year></pub-date><volume>0</volume><issue>3(124)</issue><fpage>47</fpage><lpage>50</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Салехова М.П., Максимюк Н.Н., Игимбаева Г.Т., Абдуллоев С.М., Богдашов Д.С., Салехова Д.С., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Салехова М.П., Максимюк Н.Н., Игимбаева Г.Т., Абдуллоев С.М., Богдашов Д.С., Салехова Д.С.</copyright-holder><copyright-holder xml:lang="en">Salekhova M.P., Maksimyuk N.N., Igimbaeva G.T., Abdulloev S.M., Bogdashov D.S., Salekhova D.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://vestnovsu.elpub.ru/jour/article/view/196">https://vestnovsu.elpub.ru/jour/article/view/196</self-uri><abstract><p>Проведен анализ результатов исследования инсулинорезистентности на фоне нарастания интенсивности психологического стресса. Все участницы программы исследования подписали информированное согласие и соглашение о конфиденциальности личных данных и особенностей исследований. Критерием отбора являлись высокие показатели ситуативной тревожности по шкале Спилбергера—Ханина и теста определения уровня стресса Ю.В.Щербатых при отсутствии по данным медицинского осмотра и анамнеза значимой соматической патологии, оперативных вмешательств и психологически травмирующих событий в течение последнего года. Установлено, что длительное, нарастающее по интенсивности воздействие психологического стресса имеет патогенетическое значение в развитии инсулинрезистентности, что связано с увеличением потребления глюкозы ЦНС и ее конкуренцией за обладание глюкозой с остальными клетками организма. Перспективно продолжение исследований в этом направлении.</p></abstract><trans-abstract xml:lang="en"><p>The analysis of the results of the study of insulin resistance against the background of an increase in the intensity of PS is carried out. All participants in the research program signed an informed consent and agreement on the confidentiality of personal data and research features. Patients with high levels of situational anxiety according to the Spielberger-Khanin scale and the test for determining the level of stress by Yu.V. Shcherbatykh and without significant somatic pathology according to the medical examination and anamnesis, surgical interventions and psychologically traumatic events during the last year were selected for the research. It has been established that a long-term, increasing in intensity effect of PS has a pathogenetic significance in the development of IR, which is associated with an increase in the consumption of glucose in the central nervous system and its competition for the glucose with the rest of the cells of the body. The continuation of research in this direction is promising.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>психологический стресс</kwd><kwd>катаболизм глюкозы</kwd><kwd>инсулинорезистентность</kwd><kwd>индекс HOMA-IR</kwd><kwd>сахарный диабет 2 типа</kwd></kwd-group><kwd-group xml:lang="en"><kwd>psychological stress</kwd><kwd>glucose catabolism</kwd><kwd>insulin resistance</kwd><kwd>HOMA-IR index</kwd><kwd>type 2 diabetes mellitus</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Дедов И.И., Шестакова М.В. Сахарный диабет и артериальная гипертензия. 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