vestnovsuВестник Новгородского государственного университетаVestnik of Novgorod State University2076-8052Новгородский государственный университет имени Ярослава Мудрого10.34680/2076-8052.2022.2(127).80-84vestnovsu-129Research ArticleФармакология, клиническая фармакологияPharmacology, clinical pharmacologyСодержание некоторых витаминов у больных с постковидным синдромомContent of some vitamins in patients with post-COVID syndromeОконенкоТ. И.OkonenkoT. I.АнтроповаГ. А.AntropovaG. A.ЕгороваЕ. С.EgorovaE. S.Новгородский государственный университет имени Ярослава МудрогоRussian Federation20222009202302(127)8084Copyright © Оконенко Т.И., Антропова Г.А., Егорова Е.С., 20232023Оконенко Т.И., Антропова Г.А., Егорова Е.С.Okonenko T.I., Antropova G.A., Egorova E.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestnovsu.elpub.ru/jour/article/view/129

Витамины C и А имеют иммуностимулирующий эффект, а их дефицит приводит к повышенному риску развития вирусных инфекций. Применение витаминов может снизить риск и тяжесть течения вирусных инфекций, что и показали проведенные ранее исследования. Полученные данные обусловили интерес к изучению эффективности этих витаминов у людей с новой коронавирусной (SARS-CoV-2) инфекцией. Цель статьи — оценить содержание витаминов А, С, состояние перекисного окисления в сыворотке крови больных с постковидным синдромом. Случайным образом были отобраны 30 больных в возрасте от 43 до 63 лет. Для дальнейшего анализа были сформированы 2 группы: 1-я группа — 12 человек, переболевших новой короновирусной инфекцией. 2-я группа — 18 больных, не болевших COVID-19, но предъявляющих жалобы на бессонницу, тревожность, снижение работоспособности, вялость. Оценивались результаты анализов крови. Измеряли сывороточные уровни витаминов А, С и малонового диальдегида. В образцах мочи определяли содержание витамина С. Выявлено, что у пациентов с постковидным синдромом наблюдаются существенные изменения показателей уровней витамина А и С, которые запускают процессы, приводящие к окислительному стрессу.

Vitamins C and A have an immunostimulating effect, and their deficiency leads to an increased risk of developing viral infections. Numerous studies have indicated that the administration of vitamins can decrease the risk and severity of viral infections. The data obtained have stimulated an interest in the efficacy of these vitamins in people with a new coronavirus (SARS-CoV-2) infection. The article aims to evaluate the content of vitamins A, C, as well as peroxidation activity in the blood serum of patients with post-COVID syndrome. For the analysis, 30 patients aged 43 to 63 years were randomly selected, and 2 groups were formed. Group 1 included 12 patients with post-COVID syndrome, who have had a severe disease requiring hospitalization. Group 2 included 18 patients who did not have the new coronovirus infection but complained of physical and mental fatigue, muscle weakness. The serum levels of vitamin A, C and malondialdehyde were measured. Vitamin C content was determined in urine samples. It has been found that patients with postCOVID syndrome demonstrate significant changes in vitamin A and C levels, which trigger the processes that result in oxidative stress.

COVID-19витамин Авитамин Спостковидный синдромSARS-CoV-2COVID-19vitamin Cvitamin Apost-covid syndromeReferencesManion M., Hullsiek K.H., Wilson E.M.P. et al. Vitamin D deficiency is associated with IL-6 levels and monocyte activation in HIV-infected persons // PLOS ONE. 2017. Vol.12(5). Article number: e0175517. DOI: https://doi.org/10.1371/journal.pone.0175517Manion M., Hullsiek K.H., Wilson E.M.P., et al. Vitamin D deficiency is associated with IL-6 levels and monocyte activation in HIV-infected persons. PLOS ONE, 2017, vol. 12(5), art. no. e0175517. doi: https://doi.org/10.1371/journal.pone.0175517Allard J.P., Aghdassi E., Chau J. et al. Effects of vitamin E and C supplementation on oxidative stress and viral load in HIVinfected subjects // AIDS 1998. Vol. 12(13). P.1653–1659. DOI: https://doi.org/10.1097/00002030-199813000-00013Allard J.P., Aghdassi E., Chau J., et al. Effects of vitamin E and C supplementation on oxidative stress and viral load in HIV-infected subjects. AIDS, 1998, vol. 12(13), pp. 1653– 1659. doi: https://doi.org/10.1097/00002030-19981300000013Коденцова В.М., Вржесинская О.А., Рисник Д.В. и др. Обеспеченность населения России микронутриентами и возможности ее коррекции. Состояние проблемы // Вопросы питания. 2017. Т.86. №4. С.113–124. DOI: https://doi.org/10.24411/0042-8833-2017-00067Kodencova V.M., Vrzhesinskaya O.A., Risnik D.V., Nikityuk D.B., Tutel'yan V.A. Obespechennost' naseleniya Rossii mikronutrientami i vozmozhnosti ee korrekcii Sostoyanie problemy [Micronutrient status of population of the Russian Federation and possibility of its correction. State of the problem]. Voprosy pitaniya — Problems of Nutrition, 2017, vol. 86, no. 4, pp. 113–124. doi: https://doi.org/10.24411/00428833-2017-00067Каронова Т.Л., Гринева Е.Н., Никитина И.Л. и др. Распространенность дефицита витамина D в северо-западном регионе РФ среди жителей г. Санкт-Петербурга и г. Петрозаводска // Остеопороз и остеопатии. 2013. Т.16. №3. С.3-7. DOI: https://doi.org/10.14341/osteo201333-7Karonova T.L., Grineva E.N., Nikitina I.L., Cvetkova E.V., Todieva A.M., Belyaeva O.D., et al. Rasprostranennost' deficita vitamina D v severo-zapadnom regione RF sredi zhitelej g. Sankt-Peterburga i g. Petrozavodska [The prevalence of vitamin D deficiency in the northwestern region of the Russian Federation among the residents of St. Petersburg and Рetrozavodsk]. Osteoporoz i osteopatii — Osteoporosis and Osteopathy, 2013, vol. 16, no. 3, pp. 3–7. doi: https://doi.org/10.14341/osteo201333-7Giménez V.M.M., Sanz R.L.; Marón F.J.M. et al. Vitamin DRAAS connection: an integrative standpoint into cardiovascular and neuroinflammatory disorders // Curr. Protein. Pept. Sci. 2020. Vol.21(10). P.948–954. DOI: https://doi.org/10.2174/1389203721666200606220719Giménez, V.M.M., Sanz R.L.; Marón F.J.M., et al. Vitamin D-RAAS Connection: An Integrative Standpoint into Cardiovascular and Neuroinflammatory Disorders. Curr. Protein. Pept. Sci., 2020, vol. 21(10), pp. 948–954. doi: 10.2174/1389203721666200606220719Кинаш М.И., Боярчук О.Р. Жирорастворимые витамины и иммунодефицитные состояния: механизмы влияния и возможности использования // Вопросы питания. 2020. Т.89. №3. С.22-32. DOI: https://doi.org/10.24411/00428833-2020-10026Kinash M.I., Boyarchuk O.R. Zhirorastvorimye vitaminy i immunodeficitnye sostoyaniya: mekhanizmy vliyaniya i vozmozhnosti ispol'zovaniya [Fat-soluble vitamins and immunodeficiency: mechanisms of influence and opportunities for use]. Voprosy pitaniia — Problems of Nutrition, 2020, vol. 89, no. 3, pp. 22–32. doi: https://doi.org/10.24411/0042-8833-2020-10026Semba R.D. Vitamin A and immunity to viral, bacterial and protozoan infections // Proc. Nutr. Soc. 1999. Vol.58(3). P.719727. DOI: https://doi.org/10.1017/S0029665199000944Semba R. D. Vitamin A and immunity to viral, bacterial and protozoan infections. Proc. Nutr. Soc., 1999, vol. 58(3), pp. 719–727. doi: https://doi.org/10.1017/S0029665199000944Beigmohammadi M.T., Bitarafan S., Hoseindokht A. et al. The effect of supplementation with vitamins A, B, C, D, and E on disease severity and inflammatory responses in patients with COVID-19: a randomized clinical trial // Trials. 2021. Vol.22(1). Article number: 802. DOI: https://doi.org/10.1186/s13063-021-05795-4Beigmohammadi, M.T., Bitarafan S., Hoseindokht A., et al. The effect of supplementation with vitamins A, B, C, D, and E on disease severity and inflammatory responses in patients with COVID-19: a randomized clinical trial. Trials, 2021, vol. 22(1), art. no. 802. doi: https://doi.org/10.1186/s13063021-05795-4Bae M., Kim H. The roles of vitamin C, vitamin D, and selenium in the immune system against COVID-19 // Molecules. 2020. Vol. 25(22). Article number: 5346. DOI: https://doi.org/10.3390/molecules25225346Bae M., Kim H. Mini-Review on the Roles of Vitamin C, Vitamin D, and Selenium in the Immune System against COVID-19. Molecules, 2020, vol. 25(22), art. no. 5346. doi: https://doi.org/10.3390/molecules25225346Lordan R., Rando H.M. COVID-19 Review Consortium, Greene C.S. Dietary supplements and nutraceuticals under investigation for COVID-19 prevention and treatment // mSystems 2021. Vol.6. №3. Article number: e00122-21. DOI: https://doi.org/10.1128/mSystems.00122-21Lordan R., Rando H.M. COVID-19 Review Consortium, Greene CS. Dietary supplements and nutraceuticals under investigation for COVID-19 prevention and treatment. mSystems, 2021, vol. 6, no. 3, art. no. e00122-21. doi: https://doi.org/10.1128/mSystems.00122-21Moreira A., Kekkonen R., Delgado L. et al. Nutritional modulation of exercise-induced immunodepression in athletes: a systematic review and meta-analysis // Eur J Clin Nutr. 2007. Vol. 61. P.443-460. DOI: https://doi.org/10.1038/sj.ejcn.1602549Moreira A., Kekkonen R., Delgado L., et al. Nutritional modulation of exercise-induced immunodepression in athletes: a systematic review and meta-analysis. Eur J Clin Nutr., 2007, vol. 61, pp. 443–460. doi: https://doi.org/10.1038/sj.ejcn.1602549Савченко А.А., Анисимова Е.Н., Борисов А.Г., Кондаков А.Е. Витамины как основа иммунометаболической терапии. Красноярск: Изд-во КрасГМУ, 2011. 213 с.Savchenko A.A., Anisimova E.N., Borisov A.G., Kondakov A.E. Vitaminy kak osnova immunometabolicheskoi terapii [Vitamins as the Basis of Immunometabolic Therapy]. Krasnoyarsk, KrasGMU Publ., 2011. 213 p.Стальная И.Д., Гаришвили Г.Г. Современные методы в биохимии. М.: Медицина, 1977. 240 c.Stal'naya I.D., Garishvili G.G. Sovremennye metody v biohimii [Modern methods in biochemistry]. Moscow: Medicina Publ., 1977. 240 p.Барышникова Г.А., Чорбинская С.А., Зимина Т.А. и др. COVID-19: место корректоров метаболизма в терапии больных с постковидным синдромом // Лечащий Врач. 2022. Т.25. №3. С.80-86. DOI: https://doi.org/10.51793/OS.2022.25.3.013Baryshnikova G.A., Chorbinskaya S.A., Zimina T.A., Stepanova I.I., Kudryavceva N.A. COVID-19: mesto korrektorov metabolizma v terapii bol'nyh s postkovidnym sindromom [COVID-19: the place of metabolic correctors in the therapy of patients with post-COVID syndrome]. Lechashchij vrach — Attending Physician Journal, 2022, vol. 25, no. 3, pp. 80–86. doi: https://doi.org/10.51793/OS.2022.25.3.013Barazzoni R., Bischoff S.C., Breda J. et al. ESPEN expert statements and practical guidance for nutritional management of individuals with SARS-CoV-2 infection // Clin.l Nutrition. 2020. Vol.39(6). P.1631–1638. DOI: https://doi.org/10.1016/j.clnu.2020.03.022Barazzoni R., Bischoff S.C., Breda J., et al. ESPEN expert statements and practical guidance for nutritional management of individuals with SARS-CoV-2 infection. Clin.l Nutrition, 2020, vol. 39(6), pp. 1631–1638. doi: https://doi.org/10.1016/j.clnu.2020.03.022Fernandes S.L., Ferreira A.L. dos A., Soriano E. de A. et al. The role of micronutrients on COVID-19 treatment for adults, children and elderly // Research, Society and Development. 2021. Vol.10. №2. Article number: e7010212259. DOI: https://doi.org/10.33448/rsd-v10i2.12259Fernandes S.L., Ferreira A.L. dos A., Soriano E. de A., et al. The role of micronutrients on COVID-19 treatment for adults, children and elderly. Research, Society and Development, 2021, vol. 10, no. 2. e7010212259. doi: 10.33448/rsd-v10i2.12259Arvinte C., Singh M., Marik P.E. Serum levels of vitamin C and vitamin D in a cohort of critically ill COVID-19 patients of a North American community hospital intensive care unit in May 2020: a pilot study // Med Drug Discov. 2020. Vol.8. Article number: 100064. DOI: https://doi.org/10.1016/j.medidd.2020.100064Arvinte C., Singh M., Marik P.E. Serum levels of vitamin C and vitamin D in a cohort of critically ill COVID-19 patients of a North American community hospital intensive care unit in May 2020: a pilot study. Med Drug Discov., 2020, vol. 8, art. no. 100064. doi: https://doi.org/10.1016/j.medidd.2020.100064Tyml K. Vitamin C and microvascular dysfunction in systemic inflammation // Antioxidants. 2017. Vol.6. №3. Article number: 49. DOI: https://doi.org/10.3390/antiox6030049Tyml K. Vitamin C and Microvascular Dysfunction in Systemic Inflammation. Antioxidants (Basel, Switzerland), 2017, vol. 6, no 3, art. no. 49. doi:10.3390/antiox6030049Hiedra R., Lo K.B., Elbashabsheh M. et al. The use of IV vitamin C for patients with COVID-19: a case series // Expert Rev Anti Infect Ther. 2020. Vol.18. №12. P. 1259-1261. DOI: https://doi.org/10.1080/14787210.2020.1794819Hiedra R., Lo K.B., Elbashabsheh M., et al. The use of IV vitamin C for patients with COVID-19: a case series. Expert Rev Anti Infect Ther., 2020, vol. 18, no. 12, pp. 1259–1261. doi: https://doi.org/10.1080/14787210.2020.1794819Marik P.E., Khangoora V., Rivera R. et al. Hydrocortisone, vitamin C, and thiamine for the treatment of severe sepsis and septic shock: A retrospective beforeafter study // Chest. 2017. Vol.151(6). P.1229-1238. DOI: https://doi.org/10.1016/j.chest.2016.11.036Marik P.E., Khangoora V., Rivera R., et al. Hydrocortisone, vitamin C, and thiamine for the treatment of severe sepsis and septic shock: A retrospective beforeafter study. Chest., 2017, vol. 151(6), pp. 1229–1238. doi: https://doi.org/10.1016/j.chest.2016.11.036Fowler A.A., Truwit J.D., Hite R.D. et al. Effect of vitamin C infusion on organ failure and biomarkers of inflammation and vascular injury in patients with sepsis and severe acute respiratory failure: The CITRIS-ALI randomized clinical trial // JAMA. 2019. Vol.322(13). P.1261-1270. DOI: https://doi.org/10.1001/jama.2019.11825Fowler A.A., Truwit J.D., Hite R.D., et al. Effect of vitamin C infusion on organ failure and biomarkers of inflammation and vascular injury in patients with sepsis and severe acute respiratory failure: The CITRIS-ALI Randomized Clinical Trial. JAMA, 2019, vol. 322(13), pp. 1261-1270. doi: https://doi.org/10.1001/jama.2019.11825Pisoschi A.M., Pop A., Iordache F. et al. Antioxidant, anti-inflammatory and immunomodulatory roles of vitamins in COVID-19 therapy // Eur J Med Chem. 2022. Vol.232. Article number: 114175. DOI: https://doi.org/10.1016/j.ejmech.2022.114175Pisoschi A.M., Pop A., Iordache F. et al. Antioxidant, anti-inflammatory and immunomodulatory roles of vitamins in COVID-19 therapy. Eur. J. Med. Chem., 2022, vol. 232, аrticle number: 114175. doi: https://doi.org/10.1016/j.ejmech.2022.114175Оконенко Т.И., Антропова Г.А., Егорова Е.С. Современные подходы к выбору витаминно-минеральных комплексов в работе аптечного специалиста // Вестник НовГУ. Сер.: Медицинские науки. 2020. №1(117). С.90-94.Okonenko T.I., Antropova G.A., Egorova E.S. Sovremennye podhody k vyboru vitaminno-mineral'nyh kompleksov v rabote aptechnogo specialista [Current approaches to the choice of vitamin and mineral supplements by a pharmacy professional]. Vestnik Novgorodskogo gosudarstvennogo universiteta. Ser.: Meditsinskiye nauki – Vestnik NovSU. Issue: Medical Sciences, 2020, no. 1(117), pp. 90-94.

The authors declare that there are no conflicts of interest present.